ArticleJournal of bacteriology2005
Characterization of sporulation histidine kinases of Bacillus anthracis.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Distinctive spore architecture and developmental biology ofJournal of bacteriology · 2026Article
- Artificial Sweeteners Induce Bacterial Drug Resistance and Modulate Gene Expression.Infection and drug resistance · 2026Article
- Identification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilis.PLoS biology · 2025Article
- Review
- Giving a signal: how protein phosphorylation helps Bacillus navigate through different life stages.FEMS microbiology reviews · 2023Review
- Sequence Conservation, Domain Architectures, and Phylogenetic Distribution of the HD-GYP Type c-di-GMP Phosphodiesterases.Journal of bacteriology · 2022Review
- Learning from Nature: Bacterial Spores as a Target for Current Technologies in Medicine (Review).Sovremennye tekhnologii v meditsine · 2021Review
- TheMicrobiology spectrum · 2019Review
- Flexibility and constraint: Evolutionary remodeling of the sporulation initiation pathway in Firmicutes.PLoS genetics · 2018Article
- A Dual Role for theFrontiers in microbiology · 2018Article
- Review
- Surviving Between Hosts: Sporulation and Transmission.Microbiology spectrum · 2016Review
- Quorum sensing in Bacillus thuringiensis is required for completion of a full infectious cycle in the insect.Toxins · 2014Review
- Functional characterization of WalRK: A two-component signal transduction system from Bacillus anthracis.FEBS open bio · 2014Article
- Novel modulators controlling entry into sporulation in Bacillus subtilis.Journal of bacteriology · 2013Article
- From transcriptional landscapes to the identification of biomarkers for robustness.Microbial cell factories · 2011Review
- Autoregulatory characteristics of a Bacillus anthracis serine/threonine kinase.Journal of bacteriology · 2011Article
- Bacillus anthracis comparative genome analysis in support of the Amerithrax investigation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Structural insights into inhibition of Bacillus anthracis sporulation by a novel class of non-heme globin sensor domains.The Journal of biological chemistry · 2011Article
- Bacillus anthracis sin locus and regulation of secreted proteases.Journal of bacteriology · 2011Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The initiation of sporulation in Bacillus species is regulated by the phosphorelay signal transduction pathway, which is activated by several histidine sensor kinases in response to cellular and metabolic signals. Comparison of the protein components of the phosphorelay between Bacillus subtilis and Bacillus anthracis revealed high homology in the phosphorelay orthologs of Spo0F, Spo0B, and Spo0A. The sensor domains of sensor histidine kinases are poorly conserved between species, making ortholog recognition tenuous. Putative sporulation sensor histidine kinases of B. anthracis were identified by homology to the HisKA domain of B. subtilis sporulation sensor histidine kinases, which interacts with Spo0F. Nine possible kinases were uncovered, and their genes were assayed for complementation of kinase mutants of B. subtilis, for ability to drive lacZ expression in B. subtilis and B. anthracis, and for the effect of deletion of each on the sporulation of B. anthracis. Five of the nine sensor histidine kinases were inferred to be capable of inducing sporulation in B. anthracis. Four of the sensor kinases could not be shown to induce sporulation; however, the genes for two of these were frameshifted in all B. anthracis strains and one of these was also frameshifted in the pathogenic pXO1-bearing Bacillus cereus strain G9241. It is proposed that acquisition of plasmid pXO1 and pathogenicity may require a dampening of sporulation regulation by mutational selection of sporulation sensor histidine kinase defects. The sporulation of B. anthracis ex vivo appears to result from any one or a combination of the sporulation sensor histidine kinases remaining.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.