ArticleDevelopmental cell2005
Cyclin D regulation of a sexually dimorphic asymmetric cell division.
Article in Developmental cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Article
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- mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister.BMC genomics · 2019Article
- Developmental Control of the Cell Cycle: Insights fromGenetics · 2019Review
- From the research laboratory to the database: the Caenorhabditis elegans kinome in UniProtKB.The Biochemical journal · 2017Review
- Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts.G3 (Bethesda, Md.) · 2015Article
- Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification.Biomolecules & therapeutics · 2014Review
- Transgene-mediated co-suppression of DNA topoisomerase-1 gene in Caenorhabditis elegans.International journal of biochemistry and molecular biology · 2014Article
- Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?Open biology · 2013Review
- MKP1-dependent PTH modulation of bone matrix mineralization in female mice is osteoblast maturation stage specific and involves P-ERK and P-p38 MAPKs.The Journal of endocrinology · 2013Article
- Cell-cycle regulation of NOTCH signaling during C. elegans vulval development.Molecular systems biology · 2012Article
- Physcomitrella cyclin-dependent kinase A links cell cycle reactivation to other cellular changes during reprogramming of leaf cells.The Plant cell · 2011Article
- Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans.PLoS genetics · 2011Article
- EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.Developmental biology · 2010Article
- Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans.Genetics · 2010Article
- hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.Developmental biology · 2010Article
- KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression.Journal of cell science · 2009Article
- Microdissection of shoot meristem functional domains.PLoS genetics · 2009Article
- Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans.PloS one · 2007Article
- Cyclin-dependent kinases in C. elegans.Cell division · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The C. elegans somatic gonadal precursor cell (SGP) divides asymmetrically to establish gonad-specific coordinates in both sexes. In addition, the SGP division is sexually dimorphic and initiates sex-specific programs of gonadogenesis. Wnt/MAPK signaling determines the gonadal axes, and the FKH-6 transcription factor specifies the male mode of SGP division. In this paper, we demonstrate that C. elegans cyclin D controls POP-1/TCF asymmetry in the SGP daughters as well as fkh-6 and rnr expression in the SGPs. Although cyclin D mutants have delayed SGP divisions, the cyclin D defects are not mimicked by other methods of retarding the SGP division. We find that EFL-1/E2F has an antagonistic effect on fkh-6 expression and gonadogenesis, which is relieved by cyclin D activity. We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.