Trial reportIntensive care medicine2005
Oral nystatin prophylaxis of Candida spp. colonization in ventilated critically ill patients.
Trial report in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Impact of selective digestive decontamination on respiratory tract Candida among patients with suspected ventilator-associated pneumonia. A meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Pooled it
- Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients.The Cochrane database of systematic reviews · 2016Pooled it
- Single-drug therapy or selective decontamination of the digestive tract as antifungal prophylaxis in critically ill patients: a systematic review.Critical care (London, England) · 2007Pooled it
- Effect of an oral hygienic care program for stroke patients in the intensive care unit.Yonsei medical journal · 2014Trial
- Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial.Critical care (London, England) · 2012Trial
- Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis.Digestive diseases and sciences · 2019Review
- Choosing Optimal Antifungal Agents To Prevent Fungal Infections in Nonneutropenic Critically Ill Patients: Trial Sequential Analysis, Network Meta-analysis, and Pharmacoeconomic Analysis.Antimicrobial agents and chemotherapy · 2017Article
- Invasive Candida infections in patients of a medical intensive care unit: attempt of improving diagnosis by quantifying the colonization.Wiener klinische Wochenschrift · 2015Observational
- Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later.Intensive care medicine · 2014Review
- Article
- Diagnosis of invasive candidiasis in the ICU.Annals of intensive care · 2011Article
- Article
- Yeasts in the gut: from commensals to infectious agents.Deutsches Arzteblatt international · 2009Review
- [Invasive candidiasis in the critically ill, patient non-neutropenic].Wiener medizinische Wochenschrift (1946) · 2007Review
- Prevention strategies in patients at high-risk for Candida infections: data from a neonatal intensive care setting.Intensive care medicine · 2006Article
- Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury.Intensive care medicine · 2006Article
- Oral nystatin as antifungal prophylaxis in critically ill patients: an old SDD tool to be renewed?Intensive care medicine · 2005Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveColonization of multiple body sites is a leading risk factor for Candida spp. infection in intensive care unit (ICU) patients. We evaluated whether oral nystatin prophylaxis reduces Candida spp. colonization in ventilated ICU patients. DESIGN AND
settingProspective, randomized, open-label study with blinded assessment of the objective primary evaluation criterion in the medical-surgical ICU of a teaching hospital. PATIENTS: The study included 98 consecutive patients mechanically ventilated for at least 48 h (mean age 58+/-19 years; mean SAPS II 40+/-11), assigned to either treatment group (n=51) or control group (n=47). Study groups were comparable for age, SAPS II, reason for admission, and immune status.
interventionsPatients were randomized to receive oral nystatin (treatment group; 3x10(6) U per day) or no nystatin (control group). Multiple body sites (trachea, stomach, rectum, urine, groin, and blood) were tested for Candida spp. on admission and then every 3 days by mycologists blinded to group assignment, and the colonization index was determined.
resultsColonization by Candida spp. developed in 25% of controls but in none of the treated patients. In multivariate analysis, the absence of nystatin prophylaxis and ICU length of stay were independently associated with Candida spp. colonization. No invasive candidiasis was diagnosed in either study group.
conclusionsOral nystatin prophylaxis efficiently prevented Candida spp. colonization in ICU patients at low risk of developing invasive candidiasis. Further studies are needed to determine whether this strategy remains efficient in reducing Candida spp. infections in higher risk ICU patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.