ArticleProceedings of the National Academy of Sciences of the United States of America2005
Growth-associated protein GAP-43 and L1 act synergistically to promote regenerative growth of Purkinje cell axons in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
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- Deletion of Slc1a4 Suppresses Single Mauthner Cell Axon Regeneration In Vivo through Growth-Associated Protein 43.International journal of molecular sciences · 2024Article
- Augmenting fibronectin levels in injured adult CNS promotes axon regeneration in vivo.Experimental neurology · 2024Article
- Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair.Nature communications · 2024Article
- Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway.Journal of neuroinflammation · 2024Article
- The use of viral vectors to promote repair after spinal cord injury.Experimental neurology · 2022Review
- Reduction of pTau and APP levels in mammalian brain after low-dose radiation.Scientific reports · 2021Article
- A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis.Neural regeneration research · 2020Article
- Neuroadhesive protein coating improves the chronic performance of neuroelectronics in mouse brain.Biosensors & bioelectronics · 2020Article
- MARCKS and MARCKS-like proteins in development and regeneration.Journal of biomedical science · 2018Review
- Timing of neuronal plasticity in development and aging.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturationNeuroepigenetics · 2016Article
- Myelin basic protein cleaves cell adhesion molecule L1 and promotes neuritogenesis and cell survival.The Journal of biological chemistry · 2014Article
- Analysis of human embryonic stem cells with regulatable expression of the cell adhesion molecule l1 in regeneration after spinal cord injury.Journal of neurotrauma · 2014Article
- In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Promoting remyelination for the treatment of multiple sclerosis: opportunities and challenges.Neuroscience bulletin · 2013Review
- Structural plasticity of climbing fibers and the growth-associated protein GAP-43.Frontiers in neural circuits · 2013Review
- Isoform diversity and its importance for axon regeneration.Neuropathology : official journal of the Japanese Society of Neuropathology · 2012Review
- The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.The Journal of biological chemistry · 2012Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Neuronal expression of growth-associated protein 43 (GAP-43) and the cell adhesion molecule L1 has been correlated with CNS axonal growth and regeneration, but it is not known whether expression of these molecules is necessary for axonal regeneration to occur. We have taken advantage of the fact that Purkinje cells do not express GAP-43 or L1 in adult mammals or regenerate axons into peripheral nerve grafts to test the importance of these molecules for axonal regeneration in vivo. Transgenic mice were generated in which Purkinje cells constitutively express L1 or both L1 and GAP-43 under the Purkinje cell-specific L7 promoter, and regeneration of Purkinje cell axons into peripheral nerve grafts implanted into the cerebellum was examined. Purkinje cells expressing GAP-43 or L1 showed minor enhancement of axonal sprouting. Purkinje cells expressing both GAP-43 and L1 showed more extensive axonal sprouting and axonal growth into the proximal portion of the graft. When a predegenerated nerve graft was implanted into double-transgenic mice, penetration of the graft by Purkinje cell axonal sprouts was strongly enhanced, and some axons grew along the entire intracerebral length of the graft (2.5-3.0 mm) and persisted for several months. The results demonstrate that GAP-43 and L1 coexpressed in Purkinje cells can act synergistically to switch these regeneration-incompetent CNS neurons into a regeneration-competent phenotype and show that coexpression of these molecules is a key regulator of the regenerative ability of intrinsic CNS neurons in vivo.
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