ArticleBlood2006
TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Novel contributors to B cell activation during inflammatory CNS demyelination; An oNGOing process.International journal of medical sciences · 2022Review
- B Cell-Activating Factor (BAFF)-Targeted B Cell Therapies in Inflammatory Bowel Diseases.Digestive diseases and sciences · 2016Review
- BAFF and APRIL from Activin A-Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo.Cancer research · 2016Article
- CsBAFF, a Teleost B Cell Activating Factor, Promotes Pathogen-Induced Innate Immunity and Vaccine-Induced Adaptive Immunity.PloS one · 2015Article
- Effect of TACI signaling on humoral immunity and autoimmune diseases.Journal of immunology research · 2015Review
- Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand.Nature communications · 2014Article
- Transfer of antigen from human B cells to dendritic cells.Molecular immunology · 2014Article
- B Cells Promote Th1- Skewed NKT Cell Response by CD1d-TCR Interaction.Immune network · 2013Article
- No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells.PloS one · 2013Article
- B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma.Neoplasia (New York, N.Y.) · 2011Article
- Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI.The Journal of clinical investigation · 2011Article
- BAFF and selection of autoreactive B cells.Trends in immunology · 2011Review
- Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- B cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- BAFF inhibition: a new class of drugs for the treatment of autoimmunity.Experimental cell research · 2011Review
- Targeting BAFF in autoimmunity.Current opinion in immunology · 2010Review
- Article
- Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.Diabetes · 2008Article
- Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.PloS one · 2008Article
- Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We demonstrated that B-cell-dendritic cell (DC) interactions via transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI) and B-lymphocyte stimulator (BLyS) provide an early signal critical to generate adequate numbers of mature antigen presenting cells (APCs) to prime naive CD8(+) T cells (CTLs) in vivo. Evidence that B cells are required for efficient CTL generation in mice and that reconstitution with wild-type but not TACI-knockout B cells restored normal CTL responses support our conclusion. Moreover, low doses of a TACI fusion protein (TACI-Fc) that express the extracellular domain of TACI (amino acid [aa] 1-126) restored CTL priming in B-cell-deficient mice in vivo and induced DC maturation in vitro. In fact, following interactions with B cells, splenic DCs rapidly express the CD86 costimulatory molecule, to an extent comparable to the exposure to antigenic stimuli. BLyS(high) peptide-pulsed bone marrow-derived DCs, used as vaccines in vivo, cannot generate CTLs in B-cell-deficient and TACI-deficient mice, strongly supporting a need for B-cell-DC cooperation through TACI-BLyS during CTL first encounter with antigens in vivo.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.