ArticleAnalytical chemistry2005
Congruent strategies for carbohydrate sequencing. 3. OSCAR: an algorithm for assigning oligosaccharide topology from MSn data.
Article in Analytical chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
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- GIPS-Mix for Accurate Identification of Isomeric Components in Glycan Mixtures Using Intelligent Group-Opting Strategy.Analytical chemistry · 2023Article
- Mass Spectrometry-Based Techniques to Elucidate the Sugar Code.Chemical reviews · 2022Review
- Characterization of Glycosphingolipids and Their Diverse Lipid Forms through Two-Stage Matching of LC-MS/MS Spectra.Analytical chemistry · 2021Article
- Separation and Identification of Permethylated Glycan Isomers by Reversed Phase NanoLC-NSI-MSMolecular & cellular proteomics : MCP · 2021Article
- Analysis of oligosaccharides fromJournal of ginseng research · 2020Article
- Sequence Ion Structures and Dissociation Chemistry of Deprotonated Sucrose Anions.Journal of the American Society for Mass Spectrometry · 2018Article
- Extending a Tandem Mass Spectral Library to Include MSJournal of the American Society for Mass Spectrometry · 2017Article
- A Brief Review of Bioinformatics Tools for Glycosylation Analysis by Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Mass Spectrometric Quantification of N-Linked Glycans by Reference to Exogenous Standards.Journal of proteome research · 2016Article
- Computational approaches to define a human milk metaglycome.Bioinformatics (Oxford, England) · 2016Article
- Tools to MSn Sequence and Document the Structures of Glycan Epitopes.Discovering the subtleties of sugars : proceedings of the 3rd Beilstein Glyco-Bioinformatics Symposium : June 10th - 14th, 2013, Potsdam, Germany. International Beilstein Symposium on Glyco-Bioinformatics (3rd : 2013 : Potsdam, Germany) · 2014Article
- Improved in-gel reductive β-elimination for comprehensive O-linked and sulfo-glycomics by mass spectrometry.Journal of visualized experiments : JoVE · 2014Article
- Structural documentation of glycan epitopes: sequential mass spectrometry and spectral matching.Journal of the American Society for Mass Spectrometry · 2014Article
- XGlycScan: An Open-source Software For N-linked Glycosite Assignment, Quantification and Quality Assessment of Data from Mass Spectrometry-based Glycoproteomic Analysis.MOJ proteomics & bioinformatics · 2014Article
- In-gel β-elimination and aqueous-organic partition for improved O- and sulfoglycomics.Analytical chemistry · 2013Article
- Mass spectrometry of glycans.Biochemistry. Biokhimiia · 2013Review
- Automated glycopeptide analysis--review of current state and future directions.Briefings in bioinformatics · 2013Review
- Software tools for glycan profiling.Methods in molecular biology (Clifton, N.J.) · 2013Article
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6 authors.
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Abstract
This is the third in a sequence of reports devoted to the development of congruent strategies for carbohydrate sequencing. Two previous reports outlined the strategies for observing structural detail from MSn data and introduced tools that compile, search, and compare fragment spectra in a bottom-up approach to oligosaccharide sequencing. In this third report, we introduce the operational details of an algorithm that we define as the Oligosaccharide Subtree Constraint Algorithm (OSCAR). This algorithm assimilates analyst-selected MSn ion fragmentation pathways into oligosaccharide topology (branching and linkage) using what may be considered a top-down sequencing strategy. Guided by a series of logical constraints, this de novo algorithm provides molecular topology without presumed biosynthetic constraints or external comparisons. In this introductory study, OSCAR is applied to a series of permethylated oligomers and isomeric glycans, and topologies are assigned in a few hundredths of a second.
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