ArticleEuropean journal of nuclear medicine and molecular imaging2006
Inter-institution preference-based variability of ejection fraction and volumes using quantitative gated SPECT with 99mTc-tetrofosmin: a multicentre study involving 106 hospitals.
Article in European journal of nuclear medicine and molecular imaging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 63 citations in OpenAlex.
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- Clinical use of nuclear cardiology in the assessment of heart failure.World journal of cardiology · 2010Article
- Reliability of myocardial perfusion gated SPECT for the reproducible evaluation of resting left ventricular functional parameters in long-term follow-up.European journal of nuclear medicine and molecular imaging · 2010Article
- Normal values for nuclear cardiology: Japanese databases for myocardial perfusion, fatty acid and sympathetic imaging and left ventricular function.Annals of nuclear medicine · 2010Review
- Cardiovascular events in Japanese asymptomatic patients with type 2 diabetes: a 1-year interim report of a J-ACCESS 2 investigation using myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2009Article
- Nuclear cardiology and heart failure.European journal of nuclear medicine and molecular imaging · 2009Review
- Prediction of functional recovery after revascularization using quantitative gated myocardial perfusion SPECT: a multi-center cohort study in Japan.European journal of nuclear medicine and molecular imaging · 2008Article
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2 authors at 2 institutions in 1 country.
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Abstract
purposeInter-institution reproducibility of gated SPECT quantification based on institutional preferences was evaluated. This sort of variability is crucial for a multicentre study when many hospitals are involved.
methodsA total of 106 institutes participated in this study and were grouped according to their use of five workstation types. Fifteen sets of 99mTc-tetrofosmin gated projection images with normal ejection fraction (EF) (approximately 70%, group A, n = 5), borderline low EF (approximately 50%, group B, n = 5) and low EF with large perfusion defects (approximately 30%, group C, n = 5) were prepared. The projection images were processed by QGS software in each institute based on its own routine settings. Based on 318 QGS results, the reproducibility of EF and volumes was analysed for each group and workstation.
resultsThe reproducibility of EF was good in 14 of 15 cases, showing a standard deviation (SD) of <3.6%, and the coefficient of variance of the end-diastolic volume (EDV) was <9.3% in all cases. When the deviation from the average value was analysed, the difference between EF at each institute and the average EF of the workstation (dEF) showed an SD of 2.2-3.7% for each group. The ratio of the EDV divided by the average EDV (rEDV) showed an SD of 0.061-0.069 for each group. One case in group C that had a large anterior defect with low EF showed bimodal EF distribution in one of the five workstations. The SD of EF was workstation dependent, owing to the SPECT reconstruction conditions.
conclusionThe reproducibility in EF and volumes within a workstation was good, even though the gated SPECT preferences varied. This reproducibility study supports the use of gated SPECT as a standard of ventricular function in multicentre studies.
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