ArticleThe EMBO journal2005
Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage phi29.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Phage infection fronts trigger early sporulation and viral entrapment in bacterial populations.The ISME journal · 2026Article
- Article
- Bacillus phage phi18-2 is a novel temperate virus with an unintegrated genome present in the cytoplasm of lysogenic cells as a linear phage-plasmid.Archives of virology · 2024Article
- Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection.bioRxiv : the preprint server for biology · 2024Article
- XRE transcription factors conserved in Caulobacter and φCbK modulate adhesin development and phage production.PLoS genetics · 2023Article
- Article
- Expression profiles of sporulation genes in multidrug-resistantExperimental biology and medicine (Maywood, N.J.) · 2023Article
- Phage-Encoded Sigma Factors Alter Bacterial Dormancy.mSphere · 2022Article
- The transcriptional regulator CtrA controls gene expression in Alphaproteobacteria phages: Evidence for a lytic deferment pathway.Frontiers in microbiology · 2022Article
- Unveiling Ecological and Genetic Novelty within Lytic and Lysogenic Viral Communities of Hot Spring Phototrophic Microbial Mats.Microbiology spectrum · 2021Article
- Article
- Bacterial Endospores as Phage Genome Carriers and Protective Shells.Applied and environmental microbiology · 2018Article
- Global Transcriptional Analysis of Virus-Host Interactions between Phage ϕ29 and Bacillus subtilis.Journal of virology · 2016Article
- A complex genetic switch involving overlapping divergent promoters and DNA looping regulates expression of conjugation genes of a gram-positive plasmid.PLoS genetics · 2014Article
- Review
- Vehicles, replicators, and intercellular movement of genetic information: evolutionary dissection of a bacterial cell.International journal of evolutionary biology · 2012Article
- Lysogeny and sporulation in Bacillus isolates from the Gulf of Mexico.Applied and environmental microbiology · 2010Article
- The actin-like MreB cytoskeleton organizes viral DNA replication in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Differential Spo0A-mediated effects on transcription and replication of the related Bacillus subtilis phages Nf and phi29 explain their different behaviours in vivo.Nucleic acids research · 2009Article
- DNA segregation by the bacterial actin AlfA during Bacillus subtilis growth and development.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Phage phi29 is a virulent phage of Bacillus subtilis with no known lysogenic cycle. Indeed, lysis occurs rapidly following infection of vegetative cells. Here, we show that phi29 possesses a powerful strategy that enables it to adapt its infection strategy to the physiological conditions of the infected host to optimize its survival and proliferation. Thus, the lytic cycle is suppressed when the infected cell has initiated the process of sporulation and the infecting phage genome is directed into the highly resistant spore to remain dormant until germination of the spore. We have also identified two host-encoded factors that are key players in this adaptive infection strategy. We present evidence that chromosome segregation protein Spo0J is involved in spore entrapment of the infected phi29 genome. In addition, we demonstrate that Spo0A, the master regulator for initiation of sporulation, suppresses phi29 development by repressing the main early phi29 promoters via different and novel mechanisms and also by preventing activation of the single late phi29 promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.