ArticleMediators of inflammation2005
Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis.
Article in Mediators of inflammation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00790478 (Melatonin and Ulcerative Colitis), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
Who cites it
47 citing papers in PubMed, 138 citations in OpenAlex.
- Efficacy of a Novel Melatonin-Loaded Gelatin Sponge in Palatal Wound Healing.International dental journal · 2024Trial
- Insomnia in Parkinson's Disease: Causes, Consequences, and Therapeutic Approaches.Molecular neurobiology · 2025Review
- Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.NPJ biofilms and microbiomes · 2024Review
- How Do Polyphenol-Rich Foods Prevent Oxidative Stress and Maintain Gut Health?Microorganisms · 2024Review
- Melatonin as an Antimicrobial Adjuvant and Anti-Inflammatory for the Management of RecurrentAntibiotics (Basel, Switzerland) · 2022Article
- Melatonin Decreases Acute Inflammatory Response to Neural Probe Insertion.Antioxidants (Basel, Switzerland) · 2022Article
- Intermittent Lighting Program Relieves the Deleterious Effect of Heat Stress on Growth, Stress Biomarkers, Physiological Status, and Immune Response of Broiler Chickens.Animals : an open access journal from MDPI · 2022Article
- Melatonin relieves diabetic complications and regenerates pancreatic beta cells by the reduction in NF-kB expression in streptozotocin induced diabetic rats.Saudi journal of biological sciences · 2022Article
- Anti-Inflammatory Effects of Melatonin in Rats with Induced Type 2 Diabetes Mellitus.Life (Basel, Switzerland) · 2022Article
- Assessment of Stress Salivary Markers, Perceived Stress, and Shift Work in a Cohort of Fishermen: A Preliminary Work.International journal of environmental research and public health · 2022Article
- Free amino acid composition of saliva in patients with healthy periodontium and periodontitis.Clinical oral investigations · 2021Article
- Molecular links between endocrine, nervous and immune system during chronic stress.Brain and behavior · 2021Review
- Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.Frontiers in immunology · 2021Article
- Melatonin Blocks Morphine-Induced Place Preference: Involvement of GLT-1, NF-κB, BDNF, and CREB in the Nucleus Accumbens.Frontiers in behavioral neuroscience · 2021Article
- Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis.Antioxidants (Basel, Switzerland) · 2020Article
- Is Melatonin the Cornucopia of the 21st Century?Antioxidants (Basel, Switzerland) · 2020Review
- Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?Turkish journal of medical sciences · 2020Review
- Intensive Running Enhances NF-κB Activity in the Mice Liver and the Intervention Effects of Quercetin.Nutrients · 2020Article
- Effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis.Acta biochimica et biophysica Sinica · 2020Article
- Fatigue in Inflammatory Bowel Diseases: Etiologies and Management.Advances in therapy · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proinflammatory mediators are important in the pathogenesis of IBD, which are regulated by activation of NF-kappaB. The aim of this study was to investigate whether melatonin reduces inflammatory injury and inhibits proinflammatory molecule and NF-kappaB in rats with colitis. Rat colitis model was established by TNBS enema. NF-kappaB p65, TNF-alpha, ICAM-1, and IkappaBalpha in colon tissue were examined by immunohistochemistry, EMSA, RT-PCR, and Western blot analysis. Expression of proinflammatory molecule and activation of NF-kappaB were upregulated and IkappaB level decreased in rats with colitis. Melatonin reduces colonic inflammatory injury through downregulating proinflammatory molecule mediated by NF-kappaB inhibition and blockade of IkappaBalpha degradation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.