ArticleThe American journal of pathology2005
Experimental manipulation of transforming growth factor-beta isoforms significantly affects adhesion formation in a murine surgical model.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Gynecologic postoperative anti-adhesion barriers: From biomaterials to barrier development.Biomaterials and biosystems · 2025Review
- Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions.Regenerative biomaterials · 2023Article
- Prevention of post-surgical adhesion bands by local administration of frankincense n-hexane extract.Journal of traditional and complementary medicine · 2022Article
- Monocyte-derived peritoneal macrophages protect C57BL/6 mice against surgery-induced adhesions.Frontiers in immunology · 2022Article
- Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-β and VEGF levels.Inflammopharmacology · 2021Article
- Post-Surgical Peritoneal Scarring and Key Molecular Mechanisms.Biomolecules · 2021Review
- Postoperative peritoneal adhesion: an update on physiopathology and novel traditional herbal and modern medical therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2021Review
- A review of physiological and cellular mechanisms underlying fibrotic postoperative adhesion.International journal of biological sciences · 2021Review
- Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation.Scientific reports · 2019Article
- Effect of transforming growth factor-β2 on biological regulation of multilayer primary chondrocyte culture.Cell and tissue banking · 2018Article
- Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses.The Journal of pathology · 2018Article
- Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy.Scientific reports · 2018Article
- The effects of pirfenidone on T helper cells in prevention of intraperitoneal adhesions.The Kaohsiung journal of medical sciences · 2017Article
- Effect of Emodin on Preventing Postoperative Intra-Abdominal Adhesion Formation.Oxidative medicine and cellular longevity · 2017Article
- P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride Channel-3.Theranostics · 2016Article
- Ghrelin Inhibits Post-Operative Adhesions via Blockage of the TGF-β Signaling Pathway.PloS one · 2016Article
- TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.Journal of cellular physiology · 2015Article
- Mesothelial cells in tissue repair and fibrosis.Frontiers in pharmacology · 2015Review
- Encapsulating peritoneal sclerosis-a rare but devastating peritoneal disease.Frontiers in physiology · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transforming growth factor-beta (TGF-beta), a multifunctional growth factor, represents three mammalian isoforms, TGF-beta1, TGF-beta2, and TGF-beta3. In cutaneous wound healing, combined neutralization of TGF-beta1 and -beta2 or addition of TGF-beta3 reduces scar formation. Here, we investigated whether experimental manipulation of TGF-beta isoforms reduced adhesion formation after injury to the peritoneum. Adhesions were produced in mice by surgical abrasion of adjacent serosa followed by close apposition. In the first part of this study, a detailed analysis of TGF-beta isoform distribution was performed through immunolocalization. TGF-beta isoforms clearly showed a unique temporal and spatial pattern of expression after peritoneal wounding. Based on this pharmacokinetic data, we next administered neutralizing antibodies to TGF-beta1 and -beta2 or exogenous TGF-beta3 peptide by local application and intraperitoneal injection at various times before and after surgery. At day 7 after surgery, addition of neutralizing antibodies to both TGF-beta1 and -beta2 significantly reduced the number and size of adhesions (P < 0.05) compared with the vehicle control. By contrast, exogenous addition of TGF-beta3 either had no effect or increased adhesion formation compared to the vehicle control. In conclusion, these results show that by blocking both TGF-beta1 and TGF-beta2 using neutralizing antibodies, it is possible to prevent abdominal adhesion formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.