ArticleThe American journal of pathology2005
Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Hepatocyte growth factor/c-Met signaling axis in human diseases: Mechanistic insights and therapeutic potential.Journal of cell communication and signaling · 2026Review
- Potential benefits of vitamin A and its derivatives in glaucoma.European journal of medical research · 2025Review
- Unexpected and Synergistical Effects of All-Trans Retinoic Acid and TGF-β2 on Biological Aspects of 2D and 3D Cultured ARPE19 Cells.Biomedicines · 2024Article
- Matrix Metalloproteinases and Glaucoma.Biomolecules · 2022Review
- All Trans-Retinoic Acids Facilitate the Remodeling of 2D and 3D Cultured Human Conjunctival Fibroblasts.Bioengineering (Basel, Switzerland) · 2022Article
- All-International journal of molecular sciences · 2022Article
- Synergistic effect of co-treatment with all-3 Biotech · 2019Article
- Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.Molecular vision · 2015Article
- Hepatocyte growth factor regulates the TGF-β1-induced proliferation, differentiation and secretory function of cardiac fibroblasts.International journal of molecular medicine · 2014Article
- Liarozole inhibits transforming growth factor-β3--mediated extracellular matrix formation in human three-dimensional leiomyoma cultures.Fertility and sterility · 2014Article
- Disparate effects of single endothelin-A and -B receptor blocker therapy on the progression of renal injury in advanced renovascular disease.Kidney international · 2014Article
- In silico analysis of pathways affected by differentially expressed microRNA in adrenocortical tumors.Journal of endocrinological investigation · 2013Article
- An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.British journal of pharmacology · 2013Article
- The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways.International journal of molecular sciences · 2012Review
- Retinoid and TGF-β families: crosstalk in development, neoplasia, immunity, and tissue repair.Seminars in nephrology · 2012Review
- Radiation damage and radioprotectants: new concepts in the era of molecular medicine.The British journal of radiology · 2012Article
- Role of transforming growth factor-β1 in the process of fibrosis of denervated skeletal muscle.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Article
- Amelioration of glomerulosclerosis with all-trans retinoic acid is linked to decreased plasminogen activator inhibitor-1 and α-smooth muscle actin.Acta pharmacologica Sinica · 2011Article
- Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand.The Journal of biological chemistry · 2010Article
- Transforming growth interacting factor expression in leiomyoma compared with myometrium.Fertility and sterility · 2010Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Retinoic acid (RA), an active metabolite of vitamin A, plays a critical role in the regulation of cell proliferation, survival, and differentiation. RA action is primarily mediated through its receptors, ligand-dependent transcription factors of the steroid/thyroid/vitamin D nuclear receptor superfamily. Recent studies indicate that administration of RA mitigates progressive kidney disease, underscoring its renoprotective potential. In this study, we investigated the effects of 9-cis-RA on glomerular mesangial cell activation induced by transforming growth factor (TGF)-beta1 using an in vitro cell culture system. In human mesangial cells 9-cis-RA suppressed TGF-beta1-induced alpha-smooth muscle actin, fibronectin, and plasminogen activator inhibitor-1 expression, but it did not significantly affect cell proliferation and survival. Interestingly, 9-cis-RA induced hepatocyte growth factor (HGF) mRNA expression and protein secretion, stimulated HGF promoter activity, and activated c-met receptor phosphorylation. Similar to HGF, 9-cis-RA induced expression of the Smad transcriptional co-repressor TGIF in mesangial cells. Overexpression of exogenous TGIF by transfection or 9-cis-RA treatment suppressed trans-activation of the TGF-beta-responsive promoter. Moreover, conditional ablation of the c-met receptor completely abolished the anti-fibrotic effect of 9-cis-RA and abrogated TGIF induction. Collectively, these results indicate that 9-cis-RA possesses anti-fibrotic ability by antagonizing TGF-beta1 in mesangial cells and that 9-cis-RA activity is likely mediated through a mechanism dependent on HGF/c-met receptor signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.