ArticleNucleic acids research2005
The importance of being divisible by three in alternative splicing.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
- Pervasive non-triplet alternative splicing drives functional isoform diversity.Nature communications · 2026Article
- A Review on Circular RNA Translation and Its Implications in Disease.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Article
- Systematic deletion of symmetricalNAR molecular medicine · 2024Article
- The impact of genetically controlled splicing on exon inclusion and protein structure.PloS one · 2024Article
- Alternative splicing of modulatory immune receptors in T lymphocytes: a newly identified and targetable mechanism for anticancer immunotherapy.Frontiers in immunology · 2024Review
- Article
- Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.Scientific reports · 2021Article
- Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages.G3 (Bethesda, Md.) · 2020Article
- Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus.Nature communications · 2019Article
- Alternative splicing links histone modifications to stem cell fate decision.Genome biology · 2018Article
- SpliceDetector: a software for detection of alternative splicing events in human and model organisms directly from transcript IDs.Scientific reports · 2018Article
- mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay.PLoS genetics · 2017Article
- Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide.Endocrine · 2016Article
- Promoter-like epigenetic signatures in exons displaying cell type-specific splicing.Genome biology · 2015Article
- Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast.Genome research · 2015Article
- Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species.BMC developmental biology · 2014Article
- LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq.Genome research · 2014Article
- Accurate identification and analysis of human mRNA isoforms using deep long read sequencing.G3 (Bethesda, Md.) · 2013Article
- Function of alternative splicing.Gene · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternative splicing events that are conserved in orthologous genes in different species are commonly viewed as reliable evidence of authentic, functionally significant alternative splicing events. Several recent bioinformatic analyses have shown that conserved alternative exons possess several features that distinguish them from alternative exons that are species-specific. One of the most striking differences between conserved and species-specific alternative exons is the high percentage of exons that preserve the reading frame (exons whose length is an exact multiple of 3, termed symmetrical exons) among the conserved alternative exons. Here, we examined conserved alternative exons and found several features that differentiate between symmetrical and non-symmetrical alternative exons. We show that symmetrical alternative exons have a strong tendency not to disrupt protein domain structures, whereas the tendency of non-symmetrical alternative exons to overlap with different fractions of protein domains is similar to that of constitutive exons. Additionally, skipping isoforms of non-symmetrical alternative exons are strongly underrepresented, compared with their including isoforms, suggesting that skipping of a large fraction of non-symmetrical alternative exons produces transcripts that are degraded by the nonsense-mediated mRNA decay mechanism. Non-symmetrical alternative exons also show a tendency to reside in the 5' half of the CDS. These findings suggest that alternative splicing of symmetrical and non-symmetrical exons is governed by different selective pressures and serves different purposes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.