ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Senescence-related genes and proteins in the development of Alzheimer's disease: evidence from transcriptomic and Mendelian randomization analysis.Frontiers in aging neuroscience · 2024Article
- Putative autoantibodies in the cerebrospinal fluid of Alzheimer's disease patients.F1000Research · 2019Article
- Regulation of myelin structure and conduction velocity by perinodal astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Thrombin Activity and Thrombin Receptor in Rat Glioblastoma Model: Possible Markers and Targets for Intervention?Journal of molecular neuroscience : MN · 2015Article
- Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior.Brain research · 2011Review
- Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton.PloS one · 2011Article
- Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes.ASN neuro · 2009Article
- How peptide hormone vesicles are transported to the secretion site for exocytosis.Molecular endocrinology (Baltimore, Md.) · 2008Review
- Modulation of neuritogenesis by astrocyte muscarinic receptors.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular serine proteases and their inhibitors (serpins) play a key role for synaptic plasticity in the developing and adult CNS. Serpins also counteract the extravasated proteases during brain injury. We studied the mechanisms by which one of the most important serpins, serpinE2 or protease nexin-1 (PN-1), is secreted by glial cells and how its secretion is regulated by extracellular signals. Using time-lapse videomicroscopy and biochemical methods, we demonstrate that PN-1 is constitutively secreted through small vesicles animated by a discontinuous movement using microtubules as tracks. The F-actin network underneath the plasma membrane acting as a barrier hindered PN-1 vesicle exocytosis. Vasointestinal/pituitary adenylate cyclase peptides and the G-protein activator mastoparan increased PN-1 secretion by disrupting the F-actin barrier. The receptor-mediated regulation of PN-1 constitutive secretion may be an important mechanism adapting extracellular proteolytic activity to synaptic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.