ArticleAnnals of the rheumatic diseases2006
Synovial Chlamydia trachomatis up regulates expression of a panel of genes similar to that transcribed by Mycobacterium tuberculosis during persistent infection.
Article in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 36 citations in OpenAlex.
- Quantitative Protein Profiling of Chlamydia trachomatis Growth Forms Reveals Defense Strategies Against Tryptophan Starvation.Molecular & cellular proteomics : MCP · 2016Article
- Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research.Microorganisms · 2016Review
- The molecular basis for disease phenotype in chronic Chlamydia-induced arthritis.International journal of clinical rheumatology · 2012Article
- Combination antibiotics for the treatment of Chlamydia-induced reactive arthritis: is a cure in sight?International journal of clinical rheumatology · 2011Article
- [Conception and course of eight pregnancies in five women on TNF blocker etanercept treatment].Zeitschrift fur Rheumatologie · 2010Article
- Peptidomic analysis of human peripheral monocytes persistently infected by Chlamydia trachomatis.Medical microbiology and immunology · 2007Article
- The molecular pathogenesis of Chlamydia-induced arthritis: where do we stand?Current rheumatology reports · 2007Review
- Persistent infection of Chlamydia in reactive arthritis.Annals of the rheumatic diseases · 2006Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundSynovial tissues in patients with Chlamydia associated arthritis are persistently infected by C trachomatis, an organism for which genetic manipulation is not possible. M tuberculosis also engages in persistent infection, and because this bacterium is genetically tractable many groups have been able to define transcriptional characteristics of mycobacterial growth and persistence.
objectiveTo investigate whether the pattern of gene expression underlying chlamydial persistence is similar to that underlying mycobacterial persistence.
methods194 genes in M tuberculosis that are transcriptionally up regulated to support in vivo growth and persistence of that organism have previously been identified. Each of those genes was compared with the C trachomatis genome to identify orthologues. Expression of selected chlamydial orthologues so identified was assessed by real time RT-PCR in an in vitro model of chlamydial persistence and synovial tissues from patients who were PCR positive for C trachomatis at that site.
results67 C trachomatis genes were identified as being orthologous to mycobacterial persistence related genes, representing 35% of the genes tested. The chlamydial orthologues fell into similar metabolic and other categories as those in M tuberculosis. Expression of a majority of selected chlamydial orthologues was strongly up regulated in an in vitro model of chlamydial persistence and in synovial tissues of relevant patients, compared with their expression during active infection.
conclusionsThese observations provide new insight into the molecular genetic basis underlying chlamydial persistence, and indicate that this information can be obtained, in some instances, by extrapolating observations made in other biological systems and/or organisms.
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