ArticleJournal of anatomy2005
Immunolocalization of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice.
Article in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Meckel's cartilage midsegment: spatiotemporal dynamics and osteogenic role in mice.Cell and tissue research · 2026Article
- Sphenomandibular ligament and degenerating Meckel's cartilage revisited: Sequential variations with temporal bone deformity for ligament attachment in near-term human fetuses.Journal of anatomy · 2024Article
- The relationship between Meckel's cartilage resorption and incisor tooth germ in mice.Journal of anatomy · 2023Article
- Spatial and chronological localization of septoclasts in the mouse Meckel's cartilage.Histochemistry and cell biology · 2022Article
- Diverse Fate of an Enigmatic Structure: 200 Years of Meckel's Cartilage.Frontiers in cell and developmental biology · 2020Review
- Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones.Medical molecular morphology · 2019Article
- Shedding new light on the mysteries of tooth eruption.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups.Journal of clinical medicine · 2018Article
- Meckel's cartilage breakdown offers clues to mammalian middle ear evolution.Nature ecology & evolution · 2017Article
- Expression of CGRP, vasculogenesis and osteogenesis associated mRNAs in the developing mouse mandible and tibia.European journal of histochemistry : EJH · 2017Article
- The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts.Connective tissue research · 2016Review
- The development of the mammalian outer and middle ear.Journal of anatomy · 2016Review
- Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone.Scientific reports · 2015Article
- Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice.Developmental biology · 2013Article
- RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis.Arthritis research & therapy · 2012Article
- Control of RANKL gene expression.Bone · 2010Review
- Histological changes in bone marrow after treatment of infliximab for rheumatoid arthritis.Clinical rheumatology · 2008Article
- Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.Developmental biology · 2007Article
- Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development.BMC genomics · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the immunolocalization of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) in areas of resorption caused by osteoclasts/chondroclasts on embryonic days 14-16 (E14-16) in Meckel's cartilage, and compared the results with those in endochondral bones in mice. Intense RANKL and OPG immunoreactivity was detected in the chondrocytes in Meckel's cartilage. On E15, when the incisor teeth were closest to the middle portion of Meckel's cartilage, tartrate-resistant acid phosphatase (TRAP)-positive cells appeared on the lateral side of the cartilage. Furthermore, the dental follicle showed moderate immunoreactivity for RANKL and OPG, whereas osteoblasts derived from perichondral cells were immunonegative for RANKL and OPG in that area. On E16, cartilage resorption by TRAP-positive cells had progressed at the differential position, and intensely immunoreactive products of RANKL were overlapped on and found to exist next to TRAP-positive cells in the resorption area. In developing metatarsal tissue, OPG immunoreactivity was intense in periosteal osteoblasts, whereas RANKL was only faintly seen in some of the periosteal cells. In epiphyseal chondrocytes of the developing femur, RANKL immunoreactivity was moderate, and OPG scarcely detected. These results indicate a peculiarity of RANKL and OPG immunolocalization in resorption of Meckel's cartilage. Growth of the incisor teeth may be involved in the time- and position-specific resorption of Meckel's cartilage through local regulation of the RANKL/OPG system in dental follicular cells and periosteal osteoblasts, whereas RANKL and OPG in chondrocytes seem to contribute to resorption through regulation of the chondroclast function.
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