ArticleMolecular psychiatry2006
Extreme population differences across Neuregulin 1 gene, with implications for association studies.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Investigating the Association Between rs2439302 Polymorphism and Thyroid Cancer: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2022Pooled it
- Association of the NRG1 gene and schizophrenia: a meta-analysis.Molecular psychiatry · 2006Pooled it
- New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes.Molecular genetics & genomic medicine · 2022Article
- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- Article
- Natural positive selection and north-south genetic diversity in East Asia.European journal of human genetics : EJHG · 2012Article
- Similarity in recombination rate estimates highly correlates with genetic differentiation in humans.PloS one · 2011Article
- A Study of the Association between SNP8NRG241930 in the 5' End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients.Cell journal · 2011Article
- Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome.Brain research bulletin · 2010Review
- African signatures of recent positive selection in human FOXI1.BMC evolutionary biology · 2010Article
- Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism.Journal of neural transmission (Vienna, Austria : 1996) · 2010Article
- Genome-wide comparisons of variation in linkage disequilibrium.Genome research · 2009Article
- Decay of linkage disequilibrium within genes across HGDP-CEPH human samples: most population isolates do not show increased LD.BMC genomics · 2009Article
- Family-based association study of Neuregulin 1 with psychotic bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
- Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.Journal of psychiatry & neuroscience : JPN · 2009Article
- Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene.The pharmacogenomics journal · 2008Article
- Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population.Journal of human genetics · 2008Article
- Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression.Molecular psychiatry · 2007Article
- Schizophrenia: from brain morphology to psychopathology.Current psychiatry reports · 2007Article
- Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example.Human genetics · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuregulin 1 (NRG1) is one of the most exciting candidate genes for schizophrenia in recent years since its first association with the disease in an Icelandic population. Since then, many association studies have analysed allele and haplotype frequencies in distinct populations yielding varying results: some have replicated the association, although with different alleles or haplotypes being associated, whereas others have failed to replicate the association. These contradictory results might be attributed to population differences in allele and haplotype frequencies. In order to approach this issue, we have typed 13 SNPs across this large 1.4 Mb gene, including two of the SNPs originally found associated with schizophrenia in the Icelandic population, the objective being to discover if the underlying cause of the association discrepancies to date may be due to population-specific genetic variation. The analyses have been performed in a total of 1088 individuals from 39 populations, covering most of the genetic diversity in the human species. Most of the SNPs analysed displayed differing frequencies according to geographical region. These allele differences are especially relevant in two SNPs located in a large intron of the gene, as shown by the extreme F(ST) values, which reveal genetic stratification correlated to broad continental areas. This finding may be indicative of the influence of some local selective forces on this gene. Furthermore, haplotype analysis reveals a clear clustering according to geographical areas. In summary, our findings suggest that NRG1 presents extreme population differences in allele and haplotype frequencies. We have given recommendations for taking this into account in future association studies since this diversity could give rise to erroneous results.
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