SynthesisMolecular psychiatry2006
A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.
Synthesis in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide linkage scans for renal function traits.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Pooled it
- Minor physical anomalies in autism: a meta-analysis.Molecular psychiatry · 2010Pooled it
- Heterogeneity-based genome search meta-analysis for preeclampsia.Human genetics · 2006Pooled it
- Identification of chromosomal regions linked to premature myocardial infarction: a meta-analysis of whole-genome searches.Journal of human genetics · 2006Pooled it
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- Replication of chromosomal loci involved in Parkinson's disease: A quantitative synthesis of GWAS.Toxicology reports · 2021Article
- Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.International journal of molecular sciences · 2019Review
- Opposite development of short- and long-range anterior cingulate pathways in autism.Acta neuropathologica · 2018Article
- Defective phosphoinositide metabolism in autism.Journal of neuroscience research · 2017Review
- The phenotypic manifestations of rare genic CNVs in autism spectrum disorder.Molecular psychiatry · 2015Article
- Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population.Journal of Zhejiang University. Science. B · 2014Article
- Rare mutations of CACNB2 found in autism spectrum disease-affected families alter calcium channel function.PloS one · 2014Article
- Translational approaches to the biology of Autism: false dawn or a new era?Molecular psychiatry · 2013Review
- Altered neural connectivity in excitatory and inhibitory cortical circuits in autism.Frontiers in human neuroscience · 2013Article
- Effect of schizophrenia risk-associated alleles in SREB2 (GPR85) on functional MRI phenotypes in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Insights into the genetic architecture of diabetic nephropathy.Current diabetes reports · 2012Review
- Genetic architectures of psychiatric disorders: the emerging picture and its implications.Nature reviews. Genetics · 2012Review
- Lack of correlation between metallic elements analyzed in hair by ICP-MS and autism.Journal of autism and developmental disorders · 2012Article
- Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders.Journal of neurodevelopmental disorders · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism and autism-spectrum disorders exhibit high heritability, although specific susceptibility genes still remain largely elusive. We performed a heterogeneity-based genome search meta-analysis (HEGESMA) of nine genome scans on autism or autism-spectrum disorders. Each genome scan was separated in 30 cM bins and the maximum linkage statistic from each bin was ranked. Significance for each bin's average rank and for between-scan heterogeneity (dis-similarity in the average ranks) was obtained through Monte Carlo tests. For autism, data from 771 affected sibpairs were synthesized across six separate genome scans. Region 7q22-q32 reached genome-wide significance both in weighted and unweighted analyses, with evidence for significantly low between-scan heterogeneity. The flanking chromosomal region 7q32-qter reached the less stringent threshold of suggestive significance, with no evidence for low between-scan heterogeneity. For autism-spectrum disorders (634 affected sibpairs from five separate scans), no chromosomal region reached genome-wide significance. However, suggestive significance was reached for the chromosomal regions 17p11.2-q12 and 10p12-q11.1 in weighted analyses. There was evidence for significantly high between-scan heterogeneity for the former region. The meta-analysis suggests that the 7q22-q32 region should be further scrutinized for autism susceptibility genes, while autism-spectrum disorders seem to have quite diverse linkage signals across scans, possibly suggesting genetic heterogeneity across subsyndromes and subpopulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.