ArticleMolecular psychiatry2006
Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Inter-brain synchrony to delineate the social impairment in autism spectrum disorder: a systematic review on hyperscanning studies.Psychoradiology · 2025Review
- Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.Frontiers in molecular neuroscience · 2024Review
- Untargeted urine metabolomics and machine learning provide potential metabolic signatures in children with autism spectrum disorder.Frontiers in psychiatry · 2024Article
- ASD restricted and repetitive behaviors associated at 17q21.33: genes prioritized by expression in fetal brains.Molecular psychiatry · 2018Article
- Bio-collections in autism research.Molecular autism · 2017Review
- Article
- The role of de novo mutations in the genetics of autism spectrum disorders.Nature reviews. Genetics · 2014Review
- Common variation contributes to the genetic architecture of social communication traits.Molecular autism · 2013Article
- QTL replication and targeted association highlight the nerve growth factor gene for nonverbal communication deficits in autism spectrum disorders.Molecular psychiatry · 2013Article
- The expanding genomic landscape of autism: discovering the 'forest' beyond the 'trees'Future neurology · 2013Article
- Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2011Article
- [Genetic and brain structure anomalies in autism spectrum disorders. Towards an understanding of the aetiopathogenesis?].Der Nervenarzt · 2011Review
- Article
- Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16.Human genetics · 2011Article
- Validating the Repetitive Behavior Scale-revised in young children with autism spectrum disorder.Journal of autism and developmental disorders · 2010Article
- Novel clustering of items from the Autism Diagnostic Interview-Revised to define phenotypes within autism spectrum disorders.Autism research : official journal of the International Society for Autism Research · 2009Article
- Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism.Autism research : official journal of the International Society for Autism Research · 2009Article
- The 'fractionable autism triad': a review of evidence from behavioural, genetic, cognitive and neural research.Neuropsychology review · 2008Review
- Genome-wide linkage analyses of quantitative and categorical autism subphenotypes.Biological psychiatry · 2008Article
- Current developments in the genetics of autism: from phenome to genome.Journal of neuropathology and experimental neurology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental syndrome marked by impairments in social interactive functioning and communication skills, and the presence of repetitive and restrictive behaviors. Twin and linkage studies provide evidence that ASD is heritable and genetically complex. Genetic analyses of familial quantitative traits in those with ASD may help to reveal underlying risk genes. We report a quantitative trait locus (QTL) analysis of nonverbal communication (NVC) in 228 families from the autism genetics resource exchange (AGRE) ascertained for at least two siblings with ASD. QTL at 1p13-q12, 4q21-25, 7q35, 8q23-24, and 16p12-13 indicate that genes at these loci may contribute to the variation in NVC among those with ASD. Using the criteria of Lander and Kruglyak, the QTL at 1p13-q12 is 'suggestive', while the other four are 'possible'. To assess whether these QTL are likely to harbor genes contributing specifically to the deficits in NVC, linkage analysis of ASD sibships with the most severe NVC scores was conducted. The sibships were identified by ordered-subset analyses (OSA), and families with the most severe NVC scores displayed lod scores of 3.4 at 8q23-24 and 3.8 at 16p12-13, indicating that these two regions are likely to harbor gene(s) contributing to ASD by predisposing to deficits in NVC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.