ArticleEuropean journal of endocrinology2005
Different expression of catecholamine transporters in phaeochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2.
Article in European journal of endocrinology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Comparison ofMolecular imaging and biology · 2026Article
- FROM DISCOVERY SCIENCE TO THE CLINIC - HERITABLE ENDOCRINE CANCERS AND RELATED DISORDERS: Functional imaging in hereditary endocrine neoplasms: evolving modalities and clinical implications.Endocrine-related cancer · 2026Review
- The evolution of peri-operative care in the safe management of pheochromocytoma.Surgery in practice and science · 2022Article
- New Biology of Pheochromocytoma and Paraganglioma.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Review
- A Case ofJournal of clinical medicine · 2022Article
- Review
- Hemodynamic instability during percutaneous ablation of extra-adrenal metastases of pheochromocytoma and paragangliomas: a case series.BMC anesthesiology · 2018Article
- Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.The Clinical biochemist. Reviews · 2017Review
- Functional Imaging of Paragangliomas with an Emphasis on Von Hippel-Lindau-Associated Disease: A Mini Review.Journal of kidney cancer and VHL · 2017Review
- The Author's Reply: inappropriate adrenoreceptor blockade prior to pheochromocytoma removal - 'A timely reappraisal'.Clinical endocrinology · 2016Article
- Laparoscopic adrenalectomy for pheochromocytoma-does size matter? A single surgeon comparative study.Translational andrology and urology · 2016Article
- Anesthetic considerations on adrenal gland surgery.Journal of clinical medicine research · 2015Review
- Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.Neoplasia (New York, N.Y.) · 2013Article
- Current and future anatomical and functional imaging approaches to pheochromocytoma and paraganglioma.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Usefulness of [18F]-DA and [18F]-DOPA for PET imaging in a mouse model of pheochromocytoma.Nuclear medicine and biology · 2012Article
- Phaeochromocytoma: a catecholamine and oxidative stress disorder.Endocrine regulations · 2011Article
- New imaging approaches to phaeochromocytomas and paragangliomas.Clinical endocrinology · 2010Review
- Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma.The Journal of clinical endocrinology and metabolism · 2009Article
- Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.The Journal of clinical endocrinology and metabolism · 2008Article
- Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma.American journal of physiology. Endocrinology and metabolism · 2008Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
objectivePhaeochromocytomas in patients with multiple endocrine neoplasia type 2 (MEN 2) produce adrenaline, whereas those with von Hippel-Lindau (VHL) syndrome do not. This study assessed whether these distinctions relate to differences in expression of the transporters responsible for uptake and storage of catecholamines - the noradrenaline transporter and the vesicular monoamine transporters (VMAT 1 and VMAT 2).
methodsTumour tissue and plasma samples were obtained from 31 patients with hereditary phaeochromocytoma - 18 with VHL syndrome and 13 with MEN 2. We used quantitative PCR, Western blotting, electron microscopy, immunohistochemistry and measurements of plasma and tumour catecholamines to assess differences in expression of the transporters in noradrenaline-producing vs adrenaline-producing hereditary tumours. These differences were compared with those in a further group of 26 patients with non-syndromic phaeochromocytoma.
resultsAdrenaline-producing phaeochromocytomas in MEN 2 patients expressed more noradrenaline transporter mRNA and protein than noradrenaline-producing tumours in VHL patients. In contrast, there was greater expression of VMAT 1 in VHL than MEN 2 tumours, while expression of VMAT 2 did not differ significantly. These differences were associated with larger numbers of storage vesicles and higher tissue contents of catecholamines in MEN 2 than in VHL tumours. Differences in expression of the noradrenaline transporter were weaker, and those of VMAT 1 and VMAT 2 stronger, in noradrenaline and adrenaline-producing non-syndromic than in hereditary tumours.
conclusionsThe findings show that, in addition to differences in catecholamine biosynthesis, phaeochromocytomas in MEN 2 and VHL syndrome also differ in expression of the transporters responsible for uptake and vesicular storage of catecholamines.
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