ArticleJournal of clinical pathology2005
Cytogenetic differences in breast cancer samples between German and Japanese patients.
Article in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 10 citations in OpenAlex.
- EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer.Targeted oncology · 2014Article
- Array-CGH and breast cancer.Breast cancer research : BCR · 2006Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
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Abstract
backgroundJapanese and German breast cancer cases differ substantially in the frequency of egfr amplification.
aimsTo unravel further the cytogenetic differences between Japanese and German breast cancer cases.
methodsForty one Japanese breast cancer cases were evaluated by means of comparative genomic hybridisation (CGH). The results were compared with the CGH results from 161 German breast cancer cases.
resultsThe mean number of genetic alterations/case was significantly higher in German premenopausal patients with breast cancer than in their Japanese counterparts. Japanese breast cancer cases revealed a higher number of chromosome 17p losses. Losses of 8p were associated with oestrogen receptor (ER) negativity in Japanese patients with breast cancer, whereas in the German patients gains of 3q and 6q were associated with the lack of ER expression.
conclusionsThe interethnic differences of invasive breast cancer are reflected by cytogenetic aberrations, which are also associated with the differential expression of the ER.
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