Evidence map›Paper›PMID 16189135›Full record

ArticleAntimicrobial agents and chemotherapy2005

Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.

P Holzmuller, D Sereno, J-L Lemesre

Open access · greenAbstract readComparative Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Nitric Oxide Resistance inAntioxidants (Basel, Switzerland) · 2022
    Article
  2. Article
  3. Article
  4. Resistance ofFrontiers in immunology · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. Antimony resistance and environment: Elusive links to explore during Leishmania life cycle.International journal for parasitology. Drugs and drug resistance · 2012
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

P HolzmullerUR 008 Pathogénie des Trypanosomatidés, IRD (Institut de Recherche pour le Développement), Montpellier, France.
D Sereno
J-L Lemesre
Institut de Recherche pour le Développement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.

Indexed as

Life Cycle StagesAnimalsAntimony Potassium TartrateAntiprotozoal AgentsApoptosisCell Line, TumorCells, CulturedDrug ResistanceInhibitory Concentration 50Interferon-gammaLeishmania infantumLipopolysaccharidesMacrophage ActivationMacrophagesNitric OxideAntimony Potassium TartrateAntiprotozoal AgentsInterferon-gammaLipopolysaccharidesNitric Oxide

Identifiers

PMID16189135
PMCPMC1251519
OpenAlexW2083574012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.