Evidence map›Paper›PMID 16189121›Full record

ArticleAntimicrobial agents and chemotherapy2005

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.

Oscar Zaragoza, Coralia Mihu, Arturo Casadevall, Joshua D Nosanchuk

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Synergistic antifungal interaction ofFrontiers in microbiology · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. The capsule ofVirulence · 2019
    Review
  9. Macrolides Inhibit Capsule Formation of Highly VirulentAntimicrobial agents and chemotherapy · 2019
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Oscar ZaragozaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Coralia Mihu
Arturo Casadevall
Joshua D Nosanchuk
Albert Einstein College of Medicine · US

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Antibody Protection in HistoplamosisR01AI056070 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NOSANCHUK, JOSHUA D · 2005 to 2009
$1.8M
NHLBI NIH HHS HL59842NHLBI NIH HHS R01 HL059842NIAID NIH HHS AI056070-01A2NIAID NIH HHS AI13342NIAID NIH HHS AI33774NIAID NIH HHS AI52733NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI056070
6 · The paper itself

Abstract

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

Indexed as

Amphotericin BAnimalsAntifungal AgentsCell SizeCryptococcosisCryptococcus neoformansFemaleMiceMice, Inbred C57BLAmphotericin BAntifungal Agents

Identifiers

PMID16189121
PMCPMC1251559
OpenAlexW2116453842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.