ArticleThe Journal of cell biology1992
How Listeria exploits host cell actin to form its own cytoskeleton. II. Nucleation, actin filament polarity, filament assembly, and evidence for a pointed end capper.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 107 citations in OpenAlex.
- Egress of Listeria monocytogenes from Mesenteric Lymph Nodes Depends on Intracellular Replication and Cell-to-Cell Spread.Infection and immunity · 2023Article
- CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK.World journal of surgical oncology · 2022Article
- Profilin choreographs actin and microtubules in cells and cancer.International review of cell and molecular biology · 2020Article
- Memories of Annemarie Weber.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
- Three-dimensional architecture of actin filaments in Listeria monocytogenes comet tails.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Arp2/3-mediated actin-based motility: a tail of pathogen abuse.Cell host & microbe · 2013Review
- Retroviral assembly and budding occur through an actin-driven mechanism.Biophysical journal · 2009Article
- Intracellular transport of hepatitis B virus.World journal of gastroenterology · 2007Review
- Large-scale quantitative analysis of sources of variation in the actin polymerization-based movement of Listeria monocytogenes.Biophysical journal · 2005Article
- Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex.The Journal of cell biology · 2004Article
- Actin dynamics in platelets.International review of cytology · 2002Review
- Actin-based motility of intracellular microbial pathogens.Microbiology and molecular biology reviews : MMBR · 2001Review
- Evidence for intraaxonal spread of Listeria monocytogenes from the periphery to the central nervous system.Brain pathology (Zurich, Switzerland) · 2001Article
- Actin and pollen tube growth.Protoplasma · 2001Review
- Ultrastructure of Rickettsia rickettsii actin tails and localization of cytoskeletal proteins.Infection and immunity · 2000Article
- Growing an actin gel on spherical surfaces.Biophysical journal · 2000Article
- F-actin bundles are derivatives of microvilli: What does this tell us about how bundles might form?The Journal of cell biology · 2000Review
- Molecular dissection of zyxin function reveals its involvement in cell motility.The Journal of cell biology · 1999Article
- An analysis of actin delivery in the acrosomal process of thyone.Biophysical journal · 1999Article
- Polymerizing microtubules activate site-directed F-actin assembly in nerve growth cones.Molecular biology of the cell · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
After Listeria, a bacterium, is phagocytosed by a macrophage, it dissolves the phagosomal membrane and enters the cytoplasm. The Listeria than nucleates actin filaments from its surface. These newly assembled actin filaments show unidirectional polarity with their barbed ends associated with the surface of the Listeria. Using actin concentrations below the pointed end critical concentration we find that filament elongation must be occurring by monomers adding to the barbed ends, the ends associated with the Listerial surface. If Listeria with tails are incubated in G actin under polymerizing conditions, the Listeria is translocated away from its preformed tail by the elongation of filaments attached to the Listeria. This experiment and others tell us that in vivo filament assembly must be tightly coupled to filament capping and cross-bridging so that if one process outstrips another, chaos ensues. We also show that the actin filaments in the tail are capped on their pointed ends which inhibits further elongation and/or disassembly in vitro. From these results we suggest a simple picture of how Listeria competes effectively for host cell actin. When Listeria secretes a nucleator, the host's actin subunits polymerize into a filament. Host cell machinery terminate the assembly leaving a short filament. Listeria overcomes the host control by nucleating new filaments and thus many short filaments assemble. The newest filaments push existing ones into a growing tail. Thus the competition is between nucleation of filaments caused by Listeria and the filament terminators produced by the host.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.