ArticleProceedings of the National Academy of Sciences of the United States of America2005
Clusters of interacting receptors can stabilize synaptic efficacies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
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- Linking spontaneous and stimulated spine dynamics.Communications biology · 2023Article
- The biophysical basis underlying the maintenance of early phase long-term potentiation.PLoS computational biology · 2021Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Article
- Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics.PLoS computational biology · 2017Article
- An aggregation-removal model for the formation and size determination of post-synaptic scaffold domains.PLoS computational biology · 2017Article
- Computational principles of synaptic memory consolidation.Nature neuroscience · 2016Article
- Biochemical principles underlying the stable maintenance of LTP by the CaMKII/NMDAR complex.Brain research · 2015Article
- Atypical PKCs in memory maintenance: the roles of feedback and redundancy.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Long-term memory stabilized by noise-induced rehearsal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Memory maintenance in synapses with calcium-based plasticity in the presence of background activity.PLoS computational biology · 2014Article
- Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping.Biophysical journal · 2013Article
- Unified quantitative model of AMPA receptor trafficking at synapses.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density.PLoS computational biology · 2010Article
- Mechanisms of induction and maintenance of spike-timing dependent plasticity in biophysical synapse models.Frontiers in computational neuroscience · 2010Article
- Experimental and computational aspects of signaling mechanisms of spike-timing-dependent plasticity.HFSP journal · 2009Article
- Correlated connectivity and the distribution of firing rates in the neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Translational switch for long-term maintenance of synaptic plasticity.Molecular systems biology · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic weights store memories that can last a lifetime. Yet, memory depends on synaptic protein receptors that are recycled in and out of the membrane at a fast rate, possibly several times an hour. Several proposals to bridge this vast gap in time scales between memory and its molecular substrate have relied on bistable molecular switches. Here, we propose an alternative to this approach based on clusters of interacting receptors in the synaptic membrane. We show that such clusters can be metastable and that the lifetime of such clusters can be many orders of magnitude larger than the lifetime of the receptors of which they are composed. We also demonstrate how bidirectional synaptic plasticity can be implemented in this framework.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.