ArticleJournal of virology2005
Host cell nuclear proteins are recruited to cytoplasmic vaccinia virus replication complexes.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Review
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- Breaking the barriers in cancer care: The next generation of herpes simplex virus-based oncolytic immunotherapies for cancer treatment.Molecular therapy oncolytics · 2023Review
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- Pioneer factors in viral infection.Frontiers in immunology · 2023Review
- Modulation of Early Host Innate Immune Response by an Avipox Vaccine Virus' Lateral Body Protein.Biomedicines · 2020Article
- Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol.The Journal of general virology · 2018Article
- Conserved RNA binding activity of a Yin-Yang 1 homologue in the ova of the purple sea urchin Strongylocentrotus purpuratus.Scientific reports · 2018Article
- Article
- Identifying Host Factors Associated with DNA Replicated During Virus Infection.Molecular & cellular proteomics : MCP · 2017Article
- Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication.Cell reports · 2017Article
- Amoebae, Giant Viruses, and Virophages Make Up a Complex, Multilayered Threesome.Frontiers in cellular and infection microbiology · 2017Review
- Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-κB activation and endothelial cell inflammation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Molecular characterization of the host defense activity of the barrier to autointegration factor against vaccinia virus.Journal of virology · 2011Article
- Disruption of nuclear organization during the initial phase of African swine fever virus infection.Journal of virology · 2011Article
- Specificity protein 1 is pivotal in the skin's antiviral response.The Journal of allergy and clinical immunology · 2011Article
- Article
- Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus.Virology journal · 2010Article
- Vaccinia-like cytoplasmic replication of the giant Mimivirus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Vaccinia virus protein C16 acts intracellularly to modulate the host response and promote virulence.The Journal of general virology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The initiation and termination of vaccinia virus postreplicative transcription have been reported to require cellular proteins, some of which are believed to be nuclear proteins. Vaccinia virus replicates in the cytoplasmic compartment of the cell, raising questions as to whether vaccinia virus has access to nuclear proteins. This was addressed here by following the fate of several nuclear proteins after infection of cells with vaccinia virus. The nuclear transcription factors YY1, SP1, and TATA binding protein were found to colocalize with virus replication complexes in the cytoplasm of infected cells. In addition, the nuclear proteins RNA polymerase II, TAFIIp32, and histone deacetylase 8, but not the structural protein lamin B, also were found in the cytoplasm of the cell. The association of YY1 with replication complexes was dependent on DNA replication and required only the DNA binding domain of the protein, indicating that DNA binding alone may be responsible for the association of nuclear transcription factors with viral replication complexes in the cytoplasm. The cytoplasmic localization of YY1 was resistant to the nuclear export inhibitor leptomycin B. Evidence is presented indicating that nuclear import and export pathways were not adversely affected by vaccinia virus infection. These observations indicate that vaccinia virus replication complexes have ready access to nuclear proteins by allowing leakage from the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.