ArticleJournal of virology2005
Rapid recruitment of virus-specific CD8 T cells restructures immunodominance during protective secondary responses.
Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection.Science immunology · 2022Article
- IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Type I IFN Signaling Is Dispensable during Secondary Viral Infection.PLoS pathogens · 2016Article
- Gammaherpesvirus latency differentially impacts the generation of primary versus secondary memory CD8+ T cells during subsequent infection.Journal of virology · 2014Article
- Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- CD8+ memory T cells appear exhausted within hours of acute virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Antioxidant treatment regulates the humoral immune response during acute viral infection.Journal of virology · 2013Article
- ICAM-1-dependent tuning of memory CD8 T-cell responses following acute infection.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.Journal of virology · 2012Article
- Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.Journal of virology · 2012Article
- Article
- Defects in apoptosis increase memory CD8+ T cells following infection of Bim-/-Faslpr/lpr mice.Cellular immunology · 2011Article
- IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation.Virology · 2009Article
- CD8+ T lymphocytes control murine cytomegalovirus replication in the central nervous system of newborn animals.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Tentative T cells: memory cells are quick to respond, but slow to divide.PLoS pathogens · 2008Article
- Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.The Journal of experimental medicine · 2007Article
- Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.Journal of virology · 2006Article
- Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination.Infection and immunity · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In this study we investigate the attributes of virus-specific memory CD8 T cells which most effectively control secondary infections. By rechallenging mice that had cleared primary lymphocytic choriomeningitis virus infections, we revealed that the secondary response is remarkably swift. Within 6 h following secondary infection, the production of gamma interferon becomes detectable directly ex vivo. During this protective phase of the secondary response, a very early elaboration of effector activities is preferentially exhibited by T cells specific for the viral NP396 epitope. This wave of activation contains the infection primarily before the initiation of the proliferative phase of the secondary response. Marked expansion is observed, but its magnitude differs depending on the epitope specificity of the responding cells; between 42 and 48 h following infection, approximately 70% of NP396-specific memory cells are in the S phase of the cell cycle, as assessed by bromodeoxyuridine incorporation studies. Epitope-dependent differences during the proliferative phase of the secondary response were confirmed by adoptive transfer studies with CFSE-labeled T cells. Although NP396-specific T cells typically dominate secondary responses, the broader multiepitope-specific population of antiviral T cells is beneficial for controlling a variant virus with an escape mutation in this epitope. These findings indicate that the induction and maintenance of a focused response contribute to the clearance of secondary infections; however, a more diverse pool of antiviral T cells facilitates long-term immunity to mutable pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.