ArticleGut2006
Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease.
Article in Gut, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome.Journal of veterinary internal medicineTrial
- Endogenous Aβ and Exogenous Wheat Gluten Nanostructures: Understanding Peptide Self-Assembly in Disease.ACS nano · 2025Review
- Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-mediated renal diseases.BMC gastroenterology · 2025Article
- Patterns of IgA Autoantibody Generation, Inflammatory Responses and Extracellular Matrix Metabolism in Patients with Alcohol Use Disorder.International journal of molecular sciences · 2023Article
- Primate liver tissue substrate in indirect immunofluorescence diagnostics for patients with dermatitis herpetiformis and celiac disease.Frontiers in immunology · 2023Article
- Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.International journal of molecular sciences · 2021Article
- Comprehensive Detection of Isopeptides between Human Tissue Transglutaminase and Gluten Peptides.Nutrients · 2019Article
- Celiac Disease-Musculoskeletal Manifestations and Mechanisms in Children to Adults.Current osteoporosis reports · 2018Review
- Reactive Oxygen Species Affect Transglutaminase Activity and Regulate Hematopoiesis in a Crustacean.The Journal of biological chemistry · 2016Article
- Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Extracellular matrix proteins and displacement of cultured fibroblasts from duodenal biopsies in celiac patients and controls.Journal of translational medicine · 2013Article
- Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study.Journal of clinical immunology · 2013Article
- The adaptive immune response in celiac disease.Seminars in immunopathology · 2012Review
- High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.Nature medicine · 2012Article
- Dermatitis herpetiformis: from the genetics to the development of skin lesions.Clinical & developmental immunology · 2012Review
- Recent advances in celiac disease.World journal of gastroenterology · 2011Article
- Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice.Gastroenterology · 2011Article
- Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells.The Biochemical journal · 2010Article
- Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6.Journal of clinical laboratory analysis · 2010Article
- Tissue transglutaminase expression in celiac mucosa: an immunohistochemical study.Virchows Archiv : an international journal of pathology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIntestinal inflammation in coeliac disease is driven by the gluten fraction of wheat proteins. Deamidation or cross linking of gluten peptides by tissue transglutaminase (tTG), the coeliac disease autoantigen, creates potent T cell stimulatory peptides. Therefore, our aim was to identify the reaction patterns of gluten peptides, intestinal extracellular matrix proteins, and tTG.
methodstTG activity was analysed by incorporation of monodansyl cadaverine into gliadins. Fluorescence labelled tTG reactive short gliadin peptides were used to demonstrate their deamidation and explore their cross linking patterns with tTG itself or extracellular matrix proteins. Patient sera and controls were checked for autoantibodies to matrix proteins.
resultsGliadins alpha1-alpha11, gamma1-gamma6, omega1-omega3, and omega5 were substrates for tTG. tTG catalysed the cross linking of gliadin peptides with interstitial collagen types I, III, and VI. Coeliac patients showed increased antibody titres against the collagens I, III, V, and VI.
conclusionstTG formed high molecular weight complexes with all tested gliadins. As all tested gliadins were substrates for tTG, the tTG catalysed modifications were not restricted to single gliadin types and epitopes. Furthermore, haptenisation and long term immobilisation of gliadin peptides by tTG catalysed binding to abundant extracellular matrix proteins could be instrumental in the perpetuation of intestinal inflammation and some associated autoimmune diseases in coeliac disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.