Evidence map›Paper›PMID 16187309›Full record

ReviewBirth defects research. Part C, Embryo today : reviews2005

Dlx genes, p63, and ectodermal dysplasias.

Maria I Morasso, Nadezda Radoja

Open access · greenAbstract readReview
In one paragraph

Review in Birth defects research. Part C, Embryo today : reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria I MorassoDevelopmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. morassom@mail.nih.gov
Nadezda Radoja
National Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

REGULATION OF EPIDERMAL DIFFERENTIATIONZ01AR041124 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI MORASSO, MARIA I · 2000 to 2008
$1.9M
NIAMS NIH HHS Z01 AR041124-06
6 · The paper itself

Abstract

Many events in vertebrate morphogenesis and organogenesis develop from epithelial/mesenchymal interactions. These processes involve a series of sequential and reciprocal interactions between the thickened epithelial sheets and underlying mesenchymal cells. Much has been learned from in vitro assays and knockout experiments in mice on the early signaling molecules that regulate the initial stages of the epithelial/mesenchymal interactions. In this review, we discuss effectors of these initial signals, specifically the p63 and Dlx families of transcription factors, that play central roles in embryonic patterning and regulation of different developmental processes, and provide a review of some of the mutations in these genes that have been associated with ectodermal dysplasias (EDs).

Indexed as

Gene Expression Regulation, DevelopmentalMutationAnimalsCluster AnalysisDNA-Binding ProteinsEctodermal DysplasiaEmbryonic DevelopmentEpitheliumExonsGenes, Tumor SuppressorHairHomeodomain ProteinsHumansIntronsMesodermMiceDistal-less homeobox proteinsDNA-Binding ProteinsHomeodomain ProteinsPhosphoproteinsTP63 protein, humanTrans-ActivatorsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID16187309
PMCPMC1317295
OpenAlexW2046698244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.