ArticleNeurochemical research
A sublethal dose of TNFalpha potentiates kainate-induced excitotoxicity in optic nerve oligodendrocytes.
Article in Neurochemical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells.Translational research : the journal of laboratory and clinical medicine · 2021Article
- Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation.Science advances · 2020Article
- RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLAMolecular neurobiology · 2017Article
- System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo.Experimental neurology · 2012Article
- Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.PloS one · 2012Article
- Article
- Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury.Neuroscience letters · 2008Article
- Glutamate receptor expression in multiple sclerosis lesions.Brain pathology (Zurich, Switzerland) · 2008Article
- Developmental stage of oligodendrocytes determines their response to activated microglia in vitro.Journal of neuroinflammation · 2007Article
- Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Glutamate receptor-induced cell death, known as excitotoxicity in both neurons and oligodendrocytes, has been implicated as a common pathway of cell death in numerous central nervous system (CNS) diseases and trauma. Research in both neuronal and oligodendrocyte excitotoxicity has examined glutamate's receptor-mediated effects on CNS cells, and explored strategies to protect cells exposed to the elevated glutamate levels that occur in CNS trauma and disease. Proinflammatory cytokines are also elevated in the injured CNS, and have also been implicated in CNS cell death. Recently, several laboratories have examined cytokines' effects on neuronal and glial excitotoxicity. Here, we review literature concerning the dynamic susceptibility of both neurons and oligodendrocytes to excitotoxicity, and present new data from our laboratory showing that the susceptibility of oligodendrocytes to excitotoxicity is acutely potentiated by the proinflammatory cytokine TNFalpha.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.