ArticleDigestive diseases and sciences2005
The value of ambulatory 24 hr esophageal pH monitoring in clinical practice in patients who were referred with persistent gastroesophageal reflux disease (GERD)-related symptoms while on standard dose anti-reflux medications.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Management of refractory typical GERD symptoms.Nature reviews. Gastroenterology & hepatology · 2016Review
- Diagnosis and Management of Functional Heartburn.The American journal of gastroenterology · 2016Review
- A stepwise protocol for the treatment of refractory gastroesophageal reflux-induced chronic cough.Journal of thoracic disease · 2016Article
- The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum.Clinical and translational gastroenterology · 2015Article
- Advancements in the analysis of esophageal pH monitoring in GERD.Nature reviews. Gastroenterology & hepatology · 2011Review
- Yield of 24-hour esophageal pH and bilitec monitoring in patients with persisting symptoms on PPI therapy.Digestive diseases and sciences · 2008Article
- Diagnostic options for patients with refractory GERD.Current gastroenterology reports · 2008Review
- Heartburn refractory to proton-pump inhibitors.Current treatment options in gastroenterology · 2007Article
- A comparison between a gastroesophageal reflux disease questionnaire-based algorithm and multichannel intraluminal impedance-pH monitoring for the treatment of gastroesophageal reflux-induced chronic cough.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the value of pH testing in clinical practice in gastroesophageal reflux disease patients who failed anti-reflux treatment. Patients resistant to standard dose proton pump inhibitor or an H2-blocker underwent pH testing. Randomly selected patients from the proton pump inhibitor failure group underwent the modified acid perfusion test as compared to patients with non-erosive reflux disease. In the proton pump inhibitor failure group (n = 70), 63.8% had a normal pH test as compared to 29% in the H2-blocker group (n = 31) (P = 0.007). Sensory intensity rating and acid perfusion sensitivity score were significantly higher in the non-erosive reflux disease control group than the proton pump inhibitor failure group (P < 0.05). Most patients who continued to be symptomatic on proton pump inhibitor once daily demonstrated a normal pH test and overall lack of increased chemoreceptor sensitivity to acid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.