ArticleProceedings of the National Academy of Sciences of the United States of America2005
Long-term potentiation of exogenous glutamate responses at single dendritic spines.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 169 citations in OpenAlex.
- A generalized mathematical framework for the calcium control hypothesis describes weight-dependent synaptic plasticity.Journal of computational neuroscience · 2025Article
- Stability against fluctuations: a two-dimensional study of scaling, bifurcations and spontaneous symmetry breaking in stochastic models of synaptic plasticity.Biological cybernetics · 2024Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- The Impact of Sparse Coding on Memory Lifetimes in Simple and Complex Models of Synaptic Plasticity.Biological cybernetics · 2022Article
- Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of CaFrontiers in molecular neuroscience · 2021Article
- A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.Nucleic acids research · 2020Article
- New approaches for solving old problems in neuronal protein trafficking.Molecular and cellular neurosciences · 2018Review
- AMPA Receptor Trafficking for Postsynaptic Potentiation.Frontiers in cellular neuroscience · 2018Review
- Article
- Ncm, a Photolabile Group for Preparation of Caged Molecules: Synthesis and Biological Application.PloS one · 2016Article
- Optical control of NMDA receptors with a diffusible photoswitch.Nature communications · 2015Article
- Evidence of calcium-permeable AMPA receptors in dendritic spines of CA1 pyramidal neurons.Journal of neurophysiology · 2014Article
- The role of glutamate in the morphological and physiological development of dendritic spines.The European journal of neuroscience · 2014Article
- Expression mechanisms underlying long-term potentiation: a postsynaptic view, 10 years on.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- The computational anatomy of psychosis.Frontiers in psychiatry · 2013Article
- Calcium control of triphasic hippocampal STDP.Journal of computational neuroscience · 2012Article
- Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain.Neuron · 2012Article
- Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate, and dendritic location.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Homer1 gene products orchestrate Ca(2+)-permeable AMPA receptor distribution and LTP expression.Frontiers in synaptic neuroscience · 2012Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term increases in the strength of excitatory transmission at Schaffer collateral-CA1 cell synapses of the hippocampus require the insertion of new alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) into the synapse, but the kinetics of this process are not well established. Using microphotolysis of caged glutamate to activate receptors at single dendritic spines in hippocampal CA1 cells, we report the long-lasting potentiation of AMPAR-mediated currents with only a single pairing of photoreleased glutamate and brief postsynaptic depolarization. This potentiation was N-methyl-d-aspartate receptor (NMDAR)-dependent and was reversed with low-frequency photostimulation in an NMDAR-dependent manner, suggesting that it is mediated by the same mechanism(s) as conventional synaptic long-term potentiation. Potentiation of photolytic responses developed rapidly in a stepwise manner after a brief and variable delay (<60 s) at spines, but could not be induced at extrasynaptic sites on the dendritic shaft. Potentiation was accompanied by a concomitant decrease in postsynaptic, polyamine-dependent paired-pulse facilitation of the photolytic currents, indicating that a change in the subunit composition of the AMPARs underlying the response contributed to the potentiation. These changes are consistent with an increase in the proportion of GluR2-containing AMPARs in the spine head. These results demonstrate that activation of postsynaptic glutamate receptors by glutamate is not only necessary, but sufficient, for the induction of NMDAR-dependent long-term potentiation and reveal additional aspects of its expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.