ArticleProceedings of the National Academy of Sciences of the United States of America2005
The ryanodine receptor mediates early zymogen activation in pancreatitis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 90 citations in OpenAlex.
- Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation.Autophagy · 2025Article
- Acute pancreatitis: pathogenesis and emerging therapies.Journal of pancreatology · 2024Review
- Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury.Function (Oxford, England) · 2024Article
- TRPV4 helps Piezo1 put the squeeze on pancreatic acinar cells.The Journal of clinical investigation · 2020Article
- Ringer's Lactate Prevents Early Organ Failure by Providing Extracellular Calcium.Journal of clinical medicine · 2020Article
- Research Progress on the Relationship Between Acute Pancreatitis and Calcium Overload in Acinar Cells.Digestive diseases and sciences · 2019Review
- Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.The Journal of biological chemistry · 2018Article
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- Pathophysiological mechanisms in acute pancreatitis: Current understanding.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Review
- Bidirectional Relationship Between Diabetes and Acute Pancreatitis: A Population-Based Cohort Study in Taiwan.Medicine · 2016Article
- Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin.Gastroenterology · 2015Article
- Redox signaling in acute pancreatitis.Redox biology · 2015Review
- The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells.The Biochemical journal · 2015Article
- Effect of Chaiqin Chengqi Decoction on cholecystokinin receptor 1-mediated signal transduction of pancreatic acinar cells in acute necrotizing pancreatitis rats.Chinese journal of integrative medicine · 2015Article
- The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Cluster of differentiation 38 (CD38) mediates bile acid-induced acinar cell injury and pancreatitis through cyclic ADP-ribose and intracellular calcium release.The Journal of biological chemistry · 2013Article
- Preparation of pancreatic acinar cells for the purpose of calcium imaging, cell injury measurements, and adenoviral infection.Journal of visualized experiments : JoVE · 2013Article
- Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.The Journal of biological chemistry · 2013Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Acute pancreatitis is characterized by the pathologic activation of zymogens within pancreatic acinar cells. The process requires a rise in cytosolic Ca(2+) from undefined intracellular stores. We hypothesized that zymogen activation is mediated by ryanodine receptor (RYR)-regulated Ca(2+) release, because early zymogen activation takes place in a supranuclear compartment that overlaps in distribution with the RYR. Ca(2+) signals in the basolateral, but not apical, region of acinar cells observed during supraphysiologic agonist stimulation were dependent on RYR Ca(2+) release. Inhibition of RYR or depletion of RYR-sensitive Ca(2+) pools each reduced pathologic zymogen activation in isolated acinar cells, but neither treatment affected amylase secretion. Inhibition of RYR also inhibited zymogen activation in vivo. We propose that Ca(2+) release from the RYR mediates zymogen activation but not enzyme secretion. The findings imply a role for the RYR in acute pancreatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.