ArticleDiabetes2005
Activation of the peripheral endocannabinoid system in human obesity.
Article in Diabetes, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01003873 (Effect of Weight Loss Induced Either by Gastric Bypass or Lifestyle Intervention on the Peripheral Activity of the Endocannabinoid System), which is not on this map. Cited by 248 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Weight Loss Induced Either by Gastric Bypass or Lifestyle Intervention on the Peripheral Activity of the Endocannabinoid System
Who cites it
248 citing papers in PubMed, 3 syntheses or guidelines pooled it, 686 citations in OpenAlex.
- Effect of cannabis and subproducts on anthropometric measures: a systematic review and meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Meta-analyses between 18 candidate genetic markers and overweight/obesity.Diagnostic pathology · 2014Pooled it
- Pooled it
- The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.Diabetes, obesity & metabolism · 2020Trial
- Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.Scientific reports · 2020Trial
- Trial
- Trial
- Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial.Lipids in health and disease · 2014Trial
- Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss.Obesity (Silver Spring, Md.) · 2014Trial
- Moderate-vigorous physical activity across body mass index in females: moderating effect of endocannabinoids and temperament.PloS one · 2014Trial
- Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects.British journal of clinical pharmacology · 2012Trial
- Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise.Lipids in health and disease · 2011Trial
- Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Visceral fat endocannabinoid overproduction is associated with insulin resistance and tissue dysfunction in mice and humans.Diabetologia · 2026Article
- The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Insulin increases expression of cannabinoid receptor 1 by suppressing lysosomal degradation via ERK signaling pathway.International journal of medical sciences · 2026Article
- Taurine attenuates lipid accumulation via the eCB-CB1 axis: evidence from adipose metabolomics in HFD-fed mice and 3D adipocyte spheroids.Frontiers in nutrition · 2026Article
- Endocannabinoid signaling is a critical link between circadian desynchronization and metabolic dysfunction.bioRxiv : the preprint server for biology · 2025Article
- The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas.International journal of molecular sciences · 2025Review
- Diet-dependent modulation of energy balance by CB1 signaling in peripheral sensory neurons.iScience · 2025Article
188 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central endocannabinoid system increases food intake and promotes weight gain. Blockade of the cannabinoid type 1 (CB-1) receptor reduces body weight in animals by central and peripheral actions; the role of the peripheral endocannabinoid system in human obesity is now being extensively investigated. We measured circulating endocannabinoid concentrations and studied the expression of CB-1 and the main degrading enzyme, fatty acid amide hydrolase (FAAH), in adipose tissue of lean (n = 20) and obese (n = 20) women and after a 5% weight loss in a second group of women (n = 17). Circulating levels of anandamide and 1/2-arachidonoylglycerol were increased by 35 and 52% in obese compared with lean women (P < 0.05). Adipose tissue mRNA levels were reduced by -34% for CB-1 and -59% for FAAH in obese subjects (P < 0.05). A strong negative correlation was found between FAAH expression in adipose tissue and circulating endocannabinoids. Circulating endocannabinoids and CB-1 or FAAH expression were not affected by 5% weight loss. The expression of CB-1 and FAAH was increased in mature human adipocytes compared with in preadipocytes and was found in several human tissues. Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.