ArticleThe Journal of cell biology2005
Spines and neurite branches function as geometric attractors that enhance protein kinase C action.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling.The Journal of general physiology · 2022Review
- A Bright, Nontoxic, and Non-aggregating red Fluorescent Protein for Long-Term Labeling of Fine Structures in Neurons.Frontiers in cell and developmental biology · 2022Article
- Geometric principles of second messenger dynamics in dendritic spines.Scientific reports · 2019Article
- Exploring Pharmacological Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Traumatic Brain Injury via a Network Pharmacology Approach.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.The Journal of general physiology · 2017Article
- A Model of Induction of Cerebellar Long-Term Depression Including RKIP Inactivation of Raf and MEK.Frontiers in molecular neuroscience · 2017Article
- Effect of Tamoxifen and Lithium on Treatment of Acute Mania Symptoms in Children and Adolescents.Iranian journal of child neurology · 2016Article
- Tamoxifen use for the management of mania: a review of current preclinical evidence.Psychopharmacology · 2014Review
- Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons.Neuroscience · 2011Article
- Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor.The Journal of biological chemistry · 2010Article
- Models of spatially restricted biochemical reaction systems.The Journal of biological chemistry · 2009Review
- Article
- Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder.CNS drugs · 2009Review
- A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder.Current psychiatry reports · 2008Review
- Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells.Molecular biology of the cell · 2008Article
- Article
- Immunogold electron microscopic demonstration of distinct submembranous localization of the activated gammaPKC depending on the stimulation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Hormonal regulation of nuclear permeability.The Journal of biological chemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ca2+ and diacylglycerol-regulated protein kinase Cs (PKCs; conventional PKC isoforms, such as PKCgamma) are multifunctional signaling molecules that undergo reversible plasma membrane translocation as part of their mechanism of activation. In this article, we investigate PKCgamma translocation in hippocampal neurons and show that electrical or glutamate stimulation leads to a striking enrichment of PKCgamma in synaptic spines and dendritic branches. Translocation into spines and branches was delayed when compared with the soma plasma membrane, and PKCgamma remained in these structures for a prolonged period after the response in the soma ceased. We have developed a quantitative model for the translocation process by measuring the rate at which PKCgamma crossed the neck of spines, as well as cytosolic and membrane diffusion coefficients of PKCgamma. Our study suggests that neurons make use of a high surface-to-volume ratio of spines and branches to create a geometric attraction process for PKC that imposes a delayed enhancement of PKC action at synapses and in peripheral processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.