ArticleThe Journal of experimental medicine2005
FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 10 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 10 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Association between the FAS/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- CD95 rs1800682A/G variant and tumor risk in Asians: evidence from a meta-analysis of 36 case-control studies containing 22,438 samples.Medical science monitor : international medical journal of experimental and clinical research · 2015Pooled it
- Pooled it
- Pooled it
- Association between FAS A670G polymorphism and susceptibility to cervical cancer: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Lack of association between Fas rs180082 polymorphism and risk of cervical cancer: an update by meta-analysis.BMC medical genetics · 2013Pooled it
- FAS-1377 G/A (rs2234767) polymorphism and cancer susceptibility: a meta-analysis of 17,858 cases and 24,311 controls.PloS one · 2013Pooled it
- FASL rs763110 polymorphism contributes to cancer risk: an updated meta-analysis involving 43,295 subjects.PloS one · 2013Pooled it
- The FAS ligand promoter polymorphism, rs763110 (-844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies.European journal of human genetics : EJHG · 2009Pooled it
- FAS -1,377 G/A polymorphism is associated with cancer susceptibility: evidence from 10,564 cases and 12,075 controls.Human genetics · 2009Pooled it
- Decoding the mechanisms behind second primary cancers.Journal of translational medicine · 2025Review
- Fas cell surface death receptor/Fas ligand genetic variants in gastric cancer patients: A case-control study.The Indian journal of medical research · 2022Article
- Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping.Iranian journal of basic medical sciences · 2022Article
- NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death.Nature immunology · 2018Article
- Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review.Journal of immunology research · 2017Review
- Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.BMC cancer · 2016Article
- Fas-670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development.Biomedical reports · 2016Article
- Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.International journal of cancer · 2015Article
- Article
- Genetic susceptibility to cervical cancer: role of common polymorphisms in apoptosis-related genes.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FAS receptor-ligand system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumor-immune escape and carcinogenesis. We have recently demonstrated (Sun, T., X. Miao, X. Zhang, W. Tan, P. Xiong, and D. Lin. 2004. J. Natl. Cancer Inst. 96:1030-1036; Zhang, X., X. Miao, T. Sun, W. Tan, S. Qu, P. Xiong, Y. Zhou, and D. Lin. 2005. J. Med. Genet. 42:479-484) that functional polymorphisms in FAS and FAS ligand (FASL) are associated with susceptibility to lung cancer and esophageal cancer; however, the mechanisms underlying this association have not been elucidated. We show that the FAS -1377G, FAS -670A, and FASL -844T variants are expressed more highly on ex vivo-stimulated T cells than the FAS -1377A, FAS -670G, and FASL -844C variants. Moreover, activation-induced cell death (AICD) of T cells carrying the FASL -844C allele was increased. We also found a threefold increased risk of cervical cancer among subjects with the FASL -844CC genotype compared with those with the -844TT genotype in a case-control study in Chinese women. Together, these observations suggest that genetic polymorphisms in the FAS-FASL pathway confer host susceptibility to cervical cancers, which might be caused by immune escape of tumor cells because of enhanced AICD of tumor-specific T cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.