ArticleNucleic acids research2005
Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Progress in Transcriptomics and Metabolomics in Plant Responses to Abiotic Stresses.Current issues in molecular biology · 2025Review
- The Hypervariable Tpr Multigene Family of Theileria Parasites, Defined by a Conserved, Membrane-Associated, C-Terminal Domain, Includes Several Copies with Defined Orthology Between Species.Journal of molecular evolution · 2023Article
- Article
- Re-annotation of the Theileria parva genome refines 53% of the proteome and uncovers essential components of N-glycosylation, a conserved pathway in many organisms.BMC genomics · 2020Article
- ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata.PLoS neglected tropical diseases · 2015Article
- Proteomic analysis of the Theileria annulata schizont.International journal for parasitology · 2013Article
- Article
- TparvaDB: a database to support Theileria parva vaccine development.Database : the journal of biological databases and curation · 2011Article
- MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.PLoS pathogens · 2010Article
- Characterisation of gp34, a GPI-anchored protein expressed by schizonts of Theileria parva and T. annulata.Molecular and biochemical parasitology · 2010Article
- CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity.European journal of immunology · 2009Article
- Analyses of advanced rice anther transcriptomes reveal global tapetum secretory functions and potential proteins for lipid exine formation.Plant physiology · 2009Article
- Expression analysis of the Theileria parva subtelomere-encoded variable secreted protein gene family.PloS one · 2009Article
- Properties of non-coding DNA and identification of putative cis-regulatory elements in Theileria parva.BMC genomics · 2008Article
- Comparative genomics of the Rab protein family in Apicomplexan parasites.Microbes and infection · 2008Review
- Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa.PLoS pathogens · 2007Article
- A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology.Immunome research · 2007Article
- Theileria parva and the bovine CTL response: down but not out?Parasite immunology · 2006Review
Corrections and comments
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Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massively parallel signature sequencing (MPSS) was used to analyze the transcriptome of the intracellular protozoan Theileria parva. In total 1,095,000, 20 bp sequences representing 4371 different signatures were generated from T.parva schizonts. Reproducible signatures were identified within 73% of potentially detectable predicted genes and 83% had signatures in at least one MPSS cycle. A predicted leader peptide was detected on 405 expressed genes. The quantitative range of signatures was 4-52,256 transcripts per million (t.p.m.). Rare transcripts (<50 t.p.m.) were detected from 36% of genes. Sequence signatures approximated a lognormal distribution, as in microarray. Transcripts were widely distributed throughout the genome, although only 47% of 138 telomere-associated open reading frames exhibited signatures. Antisense signatures comprised 13.8% of the total, comparable with Plasmodium. Eighty five predicted genes with antisense signatures lacked a sense signature. Antisense transcripts were independently amplified from schizont cDNA and verified by sequencing. The MPSS transcripts per million for seven genes encoding schizont antigens recognized by bovine CD8 T cells varied 1000-fold. There was concordance between transcription and protein expression for heat shock proteins that were very highly expressed according to MPSS and proteomics. The data suggests a low level of baseline transcription from the majority of protein-coding genes.
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