ArticleThe Journal of biological chemistry2005
Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Optogenetic dissection of transcriptional repression in a multicellular organism.Nature communications · 2024Article
- Epigenetic inheritance and gene expression regulation in early Drosophila embryos.EMBO reports · 2024Review
- Deciphering enhancer sequence using thermodynamics-based models and convolutional neural networks.Nucleic acids research · 2021Article
- A Looping-Based Model for Quenching Repression.PLoS computational biology · 2017Article
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- Context-dependent transcriptional interpretation of mitogen activated protein kinase signaling in the Drosophila embryo.Chaos (Woodbury, N.Y.) · 2013Article
- Long- and short-range transcriptional repressors induce distinct chromatin states on repressed genes.Current biology : CB · 2011Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3.Molecular and cellular biology · 2009Article
- Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation.The EMBO journal · 2008Article
- Enhancer responses to similarly distributed antagonistic gradients in development.PLoS computational biology · 2007Article
- Developmental expression and phylogenetic conservation of alternatively spliced forms of the C-terminal binding protein corepressor.Development genes and evolution · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Knirps and other short range transcriptional repressors play critical roles in patterning the early Drosophila embryo. These repressors are known to bind the C-terminal binding protein corepressor, but their mechanism of action is poorly understood. We purified functional recombinant Knirps protein from transgenic embryos to identify possible cofactors that contribute to the activity of this protein. The protein migrates in a complex of approximately 450 kDa and was found to copurify with the Rpd3 histone deacetylase protein during a double affinity purification procedure. Association of Rpd3 with Knirps was dependent on the presence of the C-terminal binding protein-dependent repression domain of Knirps. Previous studies of an rpd3 mutant had not shown defects in the pattern of expression of even-skipped, a target of the Knirps repressor. However, in embryos doubly heterozygous for knirps and rpd3, a marked increase in the frequency of defects in the Knirps-regulated posterior domain of even-skipped expression was found, indicating that Rpd3 contributes to Knirps repression activity in vivo. This finding implicates deacetylation in the mechanism of short range repression in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.