ArticleThe Biochemical journal2006
Proteomic analysis of mouse kidney peroxisomes: identification of RP2p as a peroxisomal nudix hydrolase with acyl-CoA diphosphatase activity.
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 83 citations in OpenAlex.
- Loss of the CoA-degrading enzyme NUDT19 exacerbates albuminuria and disrupts renal lipid homeostasis in high fat diet-fed mice.Scientific reports · 2026Article
- Comparative transcriptome and methylome of polar bears, giant and red pandas reveal diet-driven adaptive evolution.Evolutionary applications · 2024Article
- Thiophosphate Analogs of Coenzyme A and Its Precursors-Synthesis, Stability, and Biomimetic Potential.Biomolecules · 2022Article
- Turnover rate of coenzyme A in mouse brain and liver.PloS one · 2021Article
- The Pathophysiological Role of CoA.International journal of molecular sciences · 2020Review
- FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.The Journal of cell biology · 2020Article
- Peroxisomal Cofactor Transport.Biomolecules · 2020Review
- Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.Progress in lipid research · 2020Review
- Peroxisomal Metabolite and Cofactor Transport in Humans.Frontiers in cell and developmental biology · 2020Review
- Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria.FEBS letters · 2019Article
- Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver.Journal of lipid research · 2019Article
- Coenzyme A, protein CoAlation and redox regulation in mammalian cells.Biochemical Society transactions · 2018Review
- Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.The Journal of biological chemistry · 2018Article
- Muscle transcriptome analysis reveals molecular pathways and biomarkers involved in extreme ultimate pH and meat defect occurrence in chicken.Scientific reports · 2017Article
- Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.Molecular genetics and metabolism · 2017Article
- Pex35 is a regulator of peroxisome abundance.Journal of cell science · 2017Article
- Genome-wide analysis of mRNAs associated with mouse peroxisomes.BMC genomics · 2016Article
- Quantitative Proteomics Reveals the Roles of Peroxisome-associated Proteins in Antiviral Innate Immune Responses.Molecular & cellular proteomics : MCP · 2015Article
- Article
- Differential gene expression profiling of mouse uterine luminal epithelium during periimplantation.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteomic analysis of mouse kidney peroxisomes resulted in the identification of a novel nudix hydrolase designated RP2p, which is encoded by the D7RP2e gene. RP2p consists of 357 amino acids and contains two conserved domains: a nudix hydrolase domain and a CoA-binding domain. In addition, a PTS (peroxisomal targeting signal) type 1 (Ala-His-Leu) was found at the C-terminus. Analysis of the enzyme characteristics revealed that RP2p is a CoA diphosphatase with activity towards CoA, oxidized CoA and a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. The enzymatic properties of RP2p indicate that at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates. Enzyme activity was optimal at pH 9 or above, and required the presence of Mg2+ or Mn2+ ions. Subcellular fractionation studies revealed that all CoA diphosphatase activity in mouse kidney is restricted to peroxisomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.