ArticleProteins2005
Evolutionary plasticity of protein families: coupling between sequence and structure variation.
Article in Proteins, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Integrating evidence from protein domains to identify cancer driver mutations.Protein science : a publication of the Protein Society · 2026Article
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- Comparative genomic analysis and phylogeny of NAC25 gene from cultivated and wildFrontiers in plant science · 2022Article
- Revisiting the classification of adhesion GPCRs.Annals of the New York Academy of Sciences · 2019Article
- Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia.PloS one · 2019Article
- Contributions of substitutions and indels to the structural variations in ancient protein superfamilies.BMC genomics · 2018Article
- Homology modeling in a dynamical world.Protein science : a publication of the Protein Society · 2017Article
- The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.Biophysical journal · 2017Article
- Molecular evolution of a widely-adopted taxonomic marker (COI) across the animal tree of life.Scientific reports · 2016Article
- Duplication and Diversification of Dipteran Argonaute Genes, and the Evolutionary Divergence of Piwi and Aubergine.Genome biology and evolution · 2016Article
- Nucleosome adaptability conferred by sequence and structural variations in histone H2A-H2B dimers.Current opinion in structural biology · 2015Review
- Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure.Molecular biology and evolution · 2014Article
- Computational prediction of the human-microbial oral interactome.BMC systems biology · 2014Article
- Consequences of domain insertion on sequence-structure divergence in a superfold.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A stochastic evolutionary model for protein structure alignment and phylogeny.Molecular biology and evolution · 2012Article
- A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation.The Journal of experimental biology · 2012Article
- Local structural differences in homologous proteins: specificities in different SCOP classes.PloS one · 2012Article
- Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus.The Journal of experimental biology · 2011Article
- Bacterial protein structures reveal phylum dependent divergence.Computational biology and chemistry · 2011Article
- The combined effects of amino acid substitutions and indels on the evolution of structure within protein families.PloS one · 2010Article
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Authors and funding
4 authors.
Funding
Abstract
In this work we examine how protein structural changes are coupled with sequence variation in the course of evolution of a family of homologs. The sequence-structure correlation analysis performed on 81 homologous protein families shows that the majority of them exhibit statistically significant linear correlation between the measures of sequence and structural similarity. We observed, however, that there are cases where structural variability cannot be mainly explained by sequence variation, such as protein families with a number of disulfide bonds. To understand whether structures from different families and/or folds evolve in the same manner, we compared the degrees of structural change per unit of sequence change ("the evolutionary plasticity of structure") between those families with a significant linear correlation. Using rigorous statistical procedures we find that, with a few exceptions, evolutionary plasticity does not show a statistically significant difference between protein families. Similar sequence-structure analysis performed for protein loop regions shows that evolutionary plasticity of loop regions is greater than for the protein core.
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