ArticleJournal of computer-aided molecular design2005
A three-dimensional model of the human immunodeficiency virus type 1 integration complex.
Article in Journal of computer-aided molecular design, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- The conformational feasibility for the formation of reaching dimer in ASV and HIV integrase: a molecular dynamics study.Journal of biomolecular structure & dynamics · 2017Article
- C-Terminal Domain of Integrase Binds between the Two Active Sites.Journal of chemical theory and computation · 2015Article
- Structural dynamics of native and V260E mutant C-terminal domain of HIV-1 integrase.Journal of computer-aided molecular design · 2015Article
- The dynamics of interconverting D- and E-forms of the HIV-1 integrase N-terminal domain.European biophysics journal : EBJ · 2014Article
- Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.PloS one · 2013Article
- Organism-adapted specificity of the allosteric regulation of pyruvate kinase in lactic acid bacteria.PLoS computational biology · 2013Article
- Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.Acta naturae · 2011Article
- Structure-based modeling of the functional HIV-1 intasome and its inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Computer tools in the discovery of HIV-1 integrase inhibitors.Future medicinal chemistry · 2010Review
- Resistance to integrase inhibitors.Viruses · 2010Article
- Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo.Antimicrobial agents and chemotherapy · 2010Article
- Specificity of LTR DNA recognition by a peptide mimicking the HIV-1 integrase {alpha}4 helix.Nucleic acids research · 2009Article
- HIV-1 Integrase-DNA Recognition Mechanisms.Viruses · 2009Article
- The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes.The Journal of biological chemistry · 2009Article
- Molecular Interactions between HIV-1 integrase and the two viral DNA ends within the synaptic complex that mediates concerted integration.Journal of molecular biology · 2009Article
- Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.The EMBO journal · 2009Article
- An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.PloS one · 2009Article
- Integrase and integration: biochemical activities of HIV-1 integrase.Retrovirology · 2008Review
- Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.The Journal of biological chemistry · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the general features of HIV-1 integrase function are understood, there is still uncertainty about the composition of the integration complex and how integrase interacts with viral and host DNA. We propose an improved model of the integration complex based on current experimental evidence including a comparison with the homologous Tn5 transposase containing bound DNA and an analysis of DNA binding sites using Goodford's GRID. Our model comprises a pair of integrase dimers, two strands of DNA to represent the viral DNA ends and a strand of bent DNA representing the host chromosome. In our model, the terminal four base pairs of each of the viral DNA strands interact with the integrase dimer providing the active site, while bases one turn away interact with a flexible loop (residues 186-194) on the second integrase dimer. We propose that residues E152, Q148 and K156 are involved in the specific recognition of the conserved CA dinucleotide and that the active site mobile loop (residues 140-149) stabilises the integration complex by acting as a barrier to separate the two viral DNA ends. In addition, the residues responsible for DNA binding in our model show a high level of amino acid conservation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.