ArticlePharmaceutical research2005
Stability, dose uniformity, and palatability of three counterterrorism drugs-human subject and electronic tongue studies.
Article in Pharmaceutical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.Pharmaceutics · 2024Review
- Electronic Tongue-A Tool for All Tastes?Biosensors · 2017Review
- The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism.Scientific reports · 2016Article
- Orally disintegrating films and mini-tablets-innovative dosage forms of choice for pediatric use.AAPS PharmSciTech · 2015Review
- The bad taste of medicines: overview of basic research on bitter taste.Clinical therapeutics · 2013Review
- An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.AAPS PharmSciTech · 2010Article
- Oseltamivir compounding in the hospital pharmacy during the (H1N1) influenza pandemic.Clinics (Sao Paulo, Brazil) · 2010Article
- Optimizing oral medications for children.Clinical therapeutics · 2008Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThese studies evaluated the ability of common household food and drink products to mask the bitter taste of three selected anti-terrorism drugs.
methodsThree anti-terrorism drugs (doxycycline, ciprofloxacin hydrochloride, and potassium iodide) were mixed with a variety of common household food and drinks, and healthy adult volunteers evaluated the resulting taste and aftertaste. In parallel, the ASTREE Electronic Tongue was used to evaluate taste combinations. Stability of the mixtures over time was monitored, as was the dosage uniformity across preparations.
resultsFoods and drinks were identified that satisfactorily masked the bitter flavor of each drug. Dose uniformity and stability were also acceptable over the range studied, although some combinations were significantly less stable than others. The electronic tongue was able to differentiate between tastes, but ranked masking agents in a different order than human volunteers.
conclusionsDoxycycline, potassium iodide, and ciprofloxacin, which are stockpiled in solid tablet form, can conveniently be prepared into more palatable formulations, using common household foods and drinks. The electronic tongue can be used to perform an initial screening for palatability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.