ReviewEuropean journal of nuclear medicine and molecular imaging2005
Gene therapy imaging in patients for oncological applications.
Review in European journal of nuclear medicine and molecular imaging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Approaches to Imaging Immune Activation Using PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Review
- Review
- Applications of nuclear-based imaging in gene and cell therapy: probe considerations.Molecular therapy oncolytics · 2021Article
- Synthesis and Characterization of 9-(4-[Molecular imaging and biology · 2020Article
- Positron emission tomography reporter gene strategy for use in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Injected Human Muscle Precursor Cells Overexpressing PGC-1Stem cells international · 2018Article
- Review
- Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Article
- Stem Cell Imaging: Tools to Improve Cell Delivery and Viability.Stem cells international · 2016Review
- Is nano too big?European journal of nuclear medicine and molecular imaging · 2014Article
- Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals.Gene therapy · 2012Article
- Recent trends in antibody-based oncologic imaging.Cancer letters · 2012Review
- Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications.Theranostics · 2012Article
- Magnetic resonance reporter gene imaging.Theranostics · 2012Article
- Imaging: guiding the clinical translation of cardiac stem cell therapy.Circulation research · 2011Review
- Imaging long-term fate of intramyocardially implanted mesenchymal stem cells in a porcine myocardial infarction model.PloS one · 2011Article
- A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma.Cancer gene therapy · 2010Article
- Multimodality imaging of gene transfer with a receptor-based reporter gene.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2010Article
- Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy.British journal of pharmacology · 2010Review
- Future perspectives for the treatment of pulmonary arterial hypertension.Journal of the American College of Cardiology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thus far, traditional methods for evaluating gene transfer and expression have been shown to be of limited value in the clinical arena. Consequently there is a real need to develop new methods that could be repeatedly and safely performed in patients for such purposes. Molecular imaging techniques for gene expression monitoring have been developed and successfully used in animal models, but their sensitivity and reproducibility need to be tested and validated in human studies. In this review, we present the current status of gene therapy-based anticancer strategies and show how molecular imaging, and more specifically radionuclide-based approaches, can be used in gene therapy procedures for oncological applications in humans. The basis of gene expression imaging is described and specific uses of these non-invasive procedures for gene therapy monitoring illustrated. Molecular imaging of transgene expression in humans and evaluation of response to gene-based therapeutic procedures are considered. The advantages of molecular imaging for whole-body monitoring of transgene expression as a way to permit measurement of important parameters in both target and non-target organs are also analyzed. The relevance of this technology for evaluation of the necessary vector dose and how it can be used to improve vector design are also examined. Finally, the advantages of designing a gene therapy-based clinical trial with imaging fully integrated from the very beginning are discussed and future perspectives for the development of these applications outlined.
Indexed as
Identifiers
16180032What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.