ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2005
Effect of population size on the estimation of QTL: a test using resistance to barley stripe rust.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- QTL mapping and key candidate gene identification of resistance to frogeye leaf spot (Frontiers in plant science · 2026Article
- Combining two high-density QTL maps with a reference genome to identify candidate genes for morphology, yield, and biotic resistance in faba bean (Frontiers in plant science · 2026Article
- Identification and fine-mapping of novel major locus for yellow mosaic disease resistance in Glycine soja.Plant cell reports · 2025Article
- Genome-wide association mapping of loci conferring all-stage and high-temperature adult-plant resistance to stripe rust in a global spring barley collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A high-density linkage map and fine QTL mapping of architecture, phenology, and yield-related traits in faba bean (Frontiers in plant science · 2025Article
- Optimizing core collections for genetic studies: a worldwide flax germplasm case study.Frontiers in plant science · 2025Article
- Molecular breeding of flower load related traits in dioecious autotetraploidMolecular breeding : new strategies in plant improvement · 2024Article
- QTL detection and candidate gene analysis of grape white rot resistance by interspecific grape (Horticulture research · 2023Article
- Genetic analysis of heat tolerance in hot pepper: insights from comprehensive phenotyping and QTL mapping.Frontiers in plant science · 2023Article
- QTL associated with resistance to Stagonosporopsis citrulli in Citrullus amarus.Scientific reports · 2022Article
- Genetic association of toxin production in the dinoflagellateMicrobial genomics · 2022Article
- A high-density linkage map of finger millet provides QTL for blast resistance and other agronomic traits.The plant genome · 2022Article
- Whole Genome Re-sequencing and Bulk Segregant Analysis Reveals Chromosomal Location for Papaya Ringspot Virus W Resistance in Squash.Frontiers in plant science · 2022Article
- A Novel QTL for Resistance to Phytophthora Crown Rot in Squash.Plants (Basel, Switzerland) · 2021Article
- Identification of blossom-end rot loci using joint QTL-seq and linkage-based QTL mapping in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- GWAS analysis reveals distinct pathogenicity profiles of Australian Parastagonospora nodorum isolates and identification of marker-trait-associations to septoria nodorum blotch.Scientific reports · 2021Article
- Introgression of Maize Lethal Necrosis Resistance Quantitative Trait Loci Into Susceptible Maize Populations and Validation of the Resistance Under Field Conditions in Naivasha, Kenya.Frontiers in plant science · 2021Article
- An integrated linkage map of interspecific backcross 2 (BCBMC plant biology · 2020Article
- High resolution mapping of restoration of fertility (Rf) by combining large population and high density genetic map in pigeonpea [Cajanus cajan (L.) Millsp].BMC genomics · 2020Article
- New quantitative trait locus (QTLs) and candidate genes associated with the grape berry color trait identified based on a high-density genetic map.BMC plant biology · 2020Article
24 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
The limited population sizes used in many quantitative trait locus (QTL) detection experiments can lead to underestimation of QTL number, overestimation of QTL effects, and failure to quantify QTL interactions. We used the barley/barley stripe rust pathosystem to evaluate the effect of population size on the estimation of QTL parameters. We generated a large (n = 409) population of doubled haploid lines derived from the cross of two inbred lines, BCD47 and Baronesse. This population was evaluated for barley stripe rust severity in the Toluca Valley, Mexico, and in Washington State, USA, under field conditions. BCD47 was the principal donor of resistance QTL alleles, but the susceptible parent also contributed some resistance alleles. The major QTL, located on the long arm of chromosome 4H, close to the Mlo gene, accounted for up to 34% of the phenotypic variance. Subpopulations of different sizes were generated using three methods-resampling, selective genotyping, and selective phenotyping-to evaluate the effect of population size on the estimation of QTL parameters. In all cases, the number of QTL detected increased with population size. QTL with large effects were detected even in small populations, but QTL with small effects were detected only by increasing population size. Selective genotyping and/or selective phenotyping approaches could be effective strategies for reducing the costs associated with conducting QTL analysis in large populations. The method of choice will depend on the relative costs of genotyping versus phenotyping.
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