ArticleProceedings of the National Academy of Sciences of the United States of America2005
Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Drosophila pheromone-sensing neurons expressing the ppk25 ion channel subunit stimulate male courtship and female receptivity.PLoS genetics · 2014Article
- Article
- A small cohort of FRU(M) and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster.BMC neuroscience · 2013Article
- Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A Drosophila DEG/ENaC subunit functions specifically in gustatory neurons required for male courtship behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A genetic mosaic approach for neural circuit mapping in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Obesity-blocking neurons in Drosophila.Neuron · 2009Article
- Age, but not experience, affects courtship gene expression in male Drosophila melanogaster.PloS one · 2009Article
- Article
- Defective transfer of seminal-fluid materials during matings of semi-fertile fruitless mutants in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Article
- Profile of Jeffrey C. Hall.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
A gal4-containing enhancer-trap called C309 was previously shown to cause subnormal courtship of Drosophila males toward females and courtship among males when driving a conditional disrupter of synaptic transmission (shi(TS)). We extended these manipulations to analyze all features of male-specific behavior, including courtship song, which was almost eliminated by driving shi(TS) at high temperature. In the context of singing defects and homosexual courtship affected by mutations in the fru gene, a tra-regulated component of the sex-determination hierarchy, we found a C309/tra(F) combination also to induce high levels of courtship between pairs of males and "chaining" behavior in groups; however, these doubly transgenic males sang normally. Because production of male-specific FRU(M) protein is regulated by TRA, we hypothesized that a fru-derived transgene encoding the male (M) form of an Inhibitory RNA (fru(MIR)) would mimic the effects of tra(F); but C309/fru(MIR) males exhibited no courtship chaining, although they courted other males in single-pair tests. Double-labeling of neurons in which GFP was driven by C309 revealed that 10 of the 20 CNS clusters containing FRU(M) in wild-type males included coexpressing neurons. Histological analysis of the developing CNS could not rationalize the absence of tra(F) or fru(MIR) effects on courtship song, because we found C309 to be coexpressed with FRU(M) within the same 10 neuronal clusters in pupae. Thus, we hypothesize that elimination of singing behavior by the C309/shi(TS) combination involves neurons acting downstream of FRU(M) cells.
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