ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2005
Luminal hyperosmolarity decreases Na transport and impairs barrier function of sheep rumen epithelium.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 51 citations in OpenAlex.
- Assessment of an integrated therapeutic protocol for sheep with acute ruminal impaction: diagnostic and prognostic significance of rumen functions and hepatorenal biomarkers.Frontiers in veterinary science · 2025Article
- Effect of a molasses-based liquid supplement on gastrointestinal tract barrier function, inflammation, and performance of newly received feedlot cattle before and after a transport stress.Journal of animal science · 2023Article
- Subacute ruminal acidosis in dairy herds: Microbiological and nutritional causes, consequences, and prevention strategies.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Effect of aspirin to intentionally induce leaky gut on performance, inflammation, and carcass characteristics of feedlot cattle.Journal of animal science · 2021Article
- Use of aspirin to intentionally induce gastrointestinal tract barrier dysfunction in feedlot cattle.Journal of animal science · 2020Article
- The Regulation of Ruminal Short-Chain Fatty Acids on the Functions of Rumen Barriers.Frontiers in physiology · 2019Article
- Short-term adaptation of the ruminal epithelium involves abrupt changes in sodium and short-chain fatty acid transport.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- The vacuolar-type H-ATPase in ovine rumen epithelium is regulated by metabolic signals.Journal of biomedicine & biotechnology · 2010Article
- Article
- Molecular identification, immunolocalization, and functional activity of a vacuolar-type H(+)-ATPase in bovine rumen epithelium.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of luminal hyperosmolarity on Na and Cl transport were studied in rumen epithelium of sheep. An increase of luminal osmotic pressure with mannitol (350 and 450 mosm/l) caused a significant increase of tissue conductance, G (T), which is linearly correlated with flux rates of (51)Cr-EDTA and indicates an increase of passive permeability. Studies with microelectrodes revealed, that an increase of the osmotic pressure caused a significant increase of the conductance of the shunt pathway from 1.23 +/- 0.10 (control) to 1.92 +/- 0.14 mS cm(-2) (450 mosm/l) without a change of fractional resistance. Hyperosmolarity significantly increased J (sm) and reduced J (net) Na. The effect of hyperosmolarity on J (ms) Na is explained by two independent and opposed effects: increase of passive permeability and inhibition of the Na(+)/H(+) exchanger. Hypertonic buffer solution induced a decrease of the intracellular pH (pH(i)) of isolated ruminal cells, which is consistent with an inhibition of Na(+)/H(+) exchange, probably isoform NHE-3, because NHE-3-mRNA was detectable in rumen epithelium. These data are in contrast to previous reports and reveal a disturbed Na transport and an impaired barrier function of the rumen epithelium, which predisposes translocation of rumen endotoxins and penetration of bacteria.
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