ArticleInfection and immunity2005
Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Mechanisms of bacterial host-to-host transmission.Microbiology and molecular biology reviews : MMBR · 2025Review
- Challenges and Considerations in Selecting Animal Models for Evaluating a Live, Cold-Chain-Free, Dual-Use Vaccine (MyChol) for Diarrhoeal Diseases: A Comprehensive Review.The Malaysian journal of medical sciences : MJMS · 2024Review
- Clinical surveillance systems obscure the true cholera infection burden in an endemic region.Nature medicine · 2024Article
- A Well-Posed Fractional Order Cholera Model with Saturated Incidence Rate.Entropy (Basel, Switzerland) · 2023Article
- New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology.Advances in experimental medicine and biology · 2023Article
- Advances in cholera research: from molecular biology to public health initiatives.Frontiers in microbiology · 2023Review
- Mathematical Models for Cholera Dynamics-A Review.Microorganisms · 2022Review
- Animal models for dissecting Vibrio cholerae intestinal pathogenesis and immunity.Current opinion in microbiology · 2022Review
- Stochastic models of infectious diseases in a periodic environment with application to cholera epidemics.Journal of mathematical biology · 2021Article
- Immunogenicity and protective efficacy of a live, oral cholera vaccine formulation stored outside-the-cold-chain for 140 days.BMC immunology · 2020Article
- Direct transmission via households informs models of disease and intervention dynamics in cholera.PloS one · 2020Article
- Indole Inhibits ToxR Regulon Expression inInfection and immunity · 2019Article
- Temporal trend and spatial clustering of cholera epidemic in Kumasi-Ghana.Scientific reports · 2018Article
- Model distinguishability and inference robustness in mechanisms of cholera transmission and loss of immunity.Journal of theoretical biology · 2017Article
- Origins of the current seventh cholera pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Strategies to Prevent Cholera Introduction during International Personnel Deployments: A Computational Modeling Analysis Based on the 2010 Haiti Outbreak.PLoS medicine · 2016Article
- Growth in Egg Yolk Enhances Salmonella Enteritidis Colonization and Virulence in a Mouse Model of Human Colitis.PloS one · 2016Article
- The LysR-type regulator LeuO regulates the acid tolerance response in Vibrio cholerae.Microbiology (Reading, England) · 2015Article
- Vibrio cholerae-induced inflammation in the neonatal mouse cholera model.Infection and immunity · 2014Article
- Cholera transmission dynamic models for public health practitioners.Emerging themes in epidemiology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
It has previously been shown that passage of Vibrio cholerae through the human intestine imparts a transient hyperinfectious phenotype that may contribute to the epidemic spread of cholera. The mechanism underlying this human-passaged hyperinfectivity is incompletely understood, in part due to inherent difficulties in recovering and studying organisms that are freshly passed in human stool. Here, we demonstrate that passage of V. cholerae through the infant mouse intestine leads to an equivalent degree of hyperinfectivity as passage through the human host. We have used this infant mouse model of host-passaged hyperinfectivity to characterize the timing and the anatomic location of the competitive advantage of mouse-passaged V. cholerae as well as the contribution of three type IV pili to the phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.