ArticleThe Journal of nutrition2005
Biotinylation of K12 in histone H4 decreases in response to DNA double-strand breaks in human JAr choriocarcinoma cells.
Article in The Journal of nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Evaluation of clinical, laboratory, and molecular genetic features of patients with biotinidase deficiency.European journal of pediatrics · 2024Article
- Reduction of oocyte lipid droplets and meiotic failure due to biotin deficiency was not rescued by restoring the biotin nutritional status.Nutrition research and practice · 2022Article
- Epigenetic Regulation Towards Acquired Drug Resistance in Cancer.Sub-cellular biochemistry · 2022Article
- Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.World journal of gastroenterology · 2018Review
- Comprehensive Catalog of Currently Documented Histone Modifications.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Holocarboxylase synthetase is a chromatin protein and interacts directly with histone H3 to mediate biotinylation of K9 and K18.The Journal of nutritional biochemistry · 2011Article
- Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.Clinical epigenetics · 2011Article
- The polypeptide Syn67 interacts physically with human holocarboxylase synthetase, but is not a target for biotinylation.Archives of biochemistry and biophysics · 2010Article
- Differential gene expression triggered by highly cytotoxic alpha-emitter-immunoconjugates in gastric cancer cells.Investigational new drugs · 2010Article
- N- and C-terminal domains in human holocarboxylase synthetase participate in substrate recognition.Molecular genetics and metabolism · 2009Article
- Biotinyl-methyl 4-(amidomethyl)benzoate is a competitive inhibitor of human biotinidase.The Journal of nutritional biochemistry · 2008Article
- Biotin and biotinidase deficiency.Expert review of endocrinology & metabolism · 2008Article
- K12-biotinylated histone H4 marks heterochromatin in human lymphoblastoma cells.The Journal of nutritional biochemistry · 2007Article
- Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline.The American journal of clinical nutrition · 2007Article
- An avidin-based assay for histone debiotinylase activity in human cell nuclei.The Journal of nutritional biochemistry · 2007Article
- Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases.The Journal of nutrition · 2007Article
- Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance.The Journal of nutrition · 2006Article
- Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Microbiology and molecular biology reviews : MMBR · 2006Review
- Epigenetic regulation of chromatin structure and gene function by biotin.The Journal of nutrition · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypothesis that biotinylation of K12 in histone H4 plays a role in the cellular response to double-strand breaks (DSB) of DNA in human cells. DSB were caused by treating choriocarcinoma JAr cells with etoposide. Biotinylation of K12 in histone H4 decreased by 50% as early as 10-20 min after initiation of treatment with etoposide. Biotinylation returned to initial levels 30-40 min after the addition of etoposide to the medium. Temporal patterns of K12-biotinylation were similar for human lymphoma cells. Phosphorylation of S14 of histone H2B and poly(ADP-ribosylation) of glutamate residues on histone H2A are known markers of DSB in DNA; these modifications increased 10-40 min after alterations in K12-biotinylation occurred. Decreased biotinylation of K12 of histone H4 was specific for DSB but was not detectable in response to single-strand breaks or the formation of thymine dimers. Biotin-deficient choriocarcinoma cells exhibited a 40% decrease in rates of survival in response to etoposide compared with biotin-sufficient controls. These studies suggest that the lack of biotinylation of K12 in histone H4 is an early signaling event in response to DSB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.