ArticleArchives of disease in childhood2005
Longitudinal relation between limited joint mobility, height, insulin-like growth factor 1 levels, and risk of developing microalbuminuria: the Oxford Regional Prospective Study.
Article in Archives of disease in childhood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Hand pathology in type 1 diabetes mellitus: a case-control study.Hormones (Athens, Greece) · 2026Article
- A causal relationship between type 1 diabetes and risk of systemic sclerosis: a bidirectional two-sample Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
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- Juvenile diabetes and systemic sclerosis: just a coincidence?Pediatric rheumatology online journal · 2022Article
- LIMITED JOINT MOBILITY IN A CHILD WITH TYPE 1 DIABETES MELLITUS.Case reports in medicine · 2021Article
- Sclerodactyly and Diabetic Complications among Egyptian Adolescent Type 1 Diabetic Patient.Open access Macedonian journal of medical sciences · 2019Article
- Glycemic Control Maintained over Time and Joint Stiffness in Young Type 1 Patients: What Is the Mathematical Relationship?Journal of diabetes science and technology · 2019Article
- Musculoskeletal problems in diabetes mellitus.European journal of rheumatology · 2018Review
- Limited Joint Mobility Progression in Type 1 Diabetes: A 15-Year Follow-Up Study.International journal of endocrinology · 2018Article
- History, Prevalence and Assessment of Limited Joint Mobility, from Stiff Hand Syndrome to Diabetic Foot Ulcer Prevention: A Narrative Review of the Literature.Current diabetes reviews · 2018Article
- The trajectory of IGF-1 across age and duration of type 1 diabetes.Diabetes/metabolism research and reviews · 2014Article
- Diabetic foot and exercise therapy: step by step the role of rigid posture and biomechanics treatment.Current diabetes reviews · 2014Review
- Management of limited joint mobility in diabetic patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Article
- Advanced proliferative diabetic retinopathy in four young patients with flexion contractures (Rosenbloom syndrome).International ophthalmology · 2009Article
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- Article
- Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.Diabetologia · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine risk factors for development of microalbuminuria (MA) in relation to detection of limited joint mobility (LJM+) of the interphalangeal joints in a longitudinal cohort of type 1 diabetic (T1DM) subjects.
methodsA total of 479 T1DM subjects diagnosed <16 years were followed from diagnosis of diabetes with annual assessments consisting of assessment of LJM, measurement of HbA1c and insulin-like growth factor 1 (IGF-1), and three urine samples for albumin:creatinine ratio (ACR).
resultsAfter a median follow up of 10.9 years, 162 subjects (35.1%) developed LJM at median age 13.0 years and duration 5.2 years. More subjects developed LJM after compared to before puberty (67.6 v 32.4%). In LJM+ compared to LJM- subjects, HbA1c (mean 10.1 (SD 1.6) v 9.6 (1.4) %)) and ACR levels (median 1.1 (range 0.2-242.9) v 0.9 (0.4-70.7) mg/mmol) were higher, and in a Cox model probability of developing LJM was related to puberty and higher HbA1c levels. ACR levels were higher after detection of LJM compared to before (median 1.2 (range 0.4-102.6) v 0.8 (0.2-181.9) mg/mmol). Probability of developing MA was related to puberty, HbA1c, female sex, and presence of LJM (a 1.9-fold increased risk). Both LJM and MA were associated with lower height SDS (LJM: mean 0.0 (SD 1.0) v 0.2 (1.1); MA: 0.0 (1.0) v 0.2 (SD 1.0)) and lower IGF-1 levels.
conclusionThe development of LJM was associated with an increased risk of microalbuminuria, independent of glycaemic control. Risk for both microalbuminuria and LJM was associated with puberty, reduced growth, and reduced IGF-1 levels, and may indicate underlying shared pathogenic mechanisms.
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