ArticleRNA (New York, N.Y.)2005
Competition of PTB with TIA proteins for binding to a U-rich cis-element determines tissue-specific splicing of the myosin phosphatase targeting subunit 1.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis.Molecular and cellular biology · 2017Article
- Function of alternative splicing.Gene · 2013Review
- A structured RNA in hepatitis B virus post-transcriptional regulatory element represses alternative splicing in a sequence-independent and position-dependent manner.The FEBS journal · 2011Article
- Vascular smooth muscle phenotypic diversity and function.Physiological genomics · 2010Review
- iCLIP predicts the dual splicing effects of TIA-RNA interactions.PLoS biology · 2010Article
- Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping.Molecular and cellular biology · 2010Article
- The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution.PLoS genetics · 2009Article
- Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform.The Journal of biological chemistry · 2009Article
- Mutation of mapped TIA-1/TIAR binding sites in the 3' terminal stem-loop of West Nile virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification.Journal of virology · 2008Article
- Tra2beta as a novel mediator of vascular smooth muscle diversification.Circulation research · 2008Article
- A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.Genome research · 2008Article
- Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632.Journal of virology · 2008Article
- Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution.Biochemical and biophysical research communications · 2008Article
- Regulation of neuron-specific alternative splicing of neurofibromatosis type 1 pre-mRNA.Molecular and cellular biology · 2008Article
- 3' RNA elements in hepatitis C virus replication: kissing partners and long poly(U).Journal of virology · 2008Article
- A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators.Molecular biology of the cell · 2006Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
A considerable amount of smooth muscle phenotypic diversity is generated by tissue-specific and developmentally regulated splicing of alternative exons. The control mechanisms are unknown. We are using a myosin phosphatase targeting subunit-1 (MYPT1) alternative exon as a model to investigate this question. In the present study, we show that the RNA binding proteins TIA and PTB function as antagonistic enhancers and suppressors of splicing of the alternative exon, respectively. Each functions through a single U-rich element, containing two UCUU motifs, just downstream of the alternative exon 5' splice site. Tissue-specific down-regulation of TIA protein in the perinatal period allows PTB to bind to the U-rich element and suppress splicing of the alternative exon as the visceral smooth muscle acquires the fast-phasic smooth muscle contractile phenotype. This provides a novel role for PTB in the tissue-specific regulation of splicing of alternative exons during the generation of smooth muscle phenotypic diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.