ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Presubiculum stimulation in vivo evokes distinct oscillations in superficial and deep entorhinal cortex layers in chronic epileptic rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Simultaneous Observation of Mouse Cortical and Hippocampal Neural Dynamics under Anesthesia through a Cranial Microprism Window.Biosensors · 2022Article
- Functional Connectivity of the Parasubiculum and Its Role in Temporal Lobe Epilepsy.Neuroscience · 2019Article
- Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy.Journal of neurophysiology · 2015Article
- Regular-spiking cells in the presubiculum are hyperexcitable in a rat model of temporal lobe epilepsy.Journal of neurophysiology · 2014Article
- Features of proximal and distal excitatory synaptic inputs to layer V neurons of the rat medial entorhinal cortex.The Journal of physiology · 2013Article
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- Modulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats.Journal of neurophysiology · 2009Article
- Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex.The Journal of physiology · 2008Article
- The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex.Neural plasticity · 2008Article
- What does the anatomical organization of the entorhinal cortex tell us?Neural plasticity · 2008Review
- Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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6 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The characteristic cell loss in layer III of the medial entorhinal area (MEA-III) in human mesial temporal lobe epilepsy is reproduced in the rat kainate model of the disease. To understand how this cell loss affects the functional properties of the MEA, we investigated whether projections from the presubiculum (prS), providing a main input to the MEA-III, are altered in this epileptic rat model. Injections of an anterograde tracer in the prS revealed bilateral projection fibers mainly to the MEA-III in both control and chronic epileptic rats. We further examined the prS-MEA circuitry using a 16-channel electrode probe covering the MEA in anesthetized control and chronic epileptic rats. With a second 16-channel probe, we recorded signals in the hippocampus. Current source density analysis indicated that, after prS double-pulse stimulation, afterdischarges in the form of oscillations (20-45 Hz) occurred that were confined to the superficial layers of the MEA in all epileptic rats displaying MEA-III neuronal loss. Slower oscillations (theta range) were occasionally observed in the deep MEA layers and the dentate gyrus. This kind of oscillation was never observed in control rats. We conclude that dynamical changes occur in an extensive network within the temporal lobe in epileptic rats, manifested as different kinds of oscillations, the characteristics of which depend on local properties of particular subareas. These findings emphasize the significance of the entorhinal cortex in temporal lobe epilepsy and suggest that the superficial cell layers could play an important role in distributing oscillatory activity.
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